Molecular Biology Reports

, Volume 45, Issue 2, pp 99–108 | Cite as

Genetic structure and polymorphism analysis of Xinjiang Hui ethnic minority based on 21 STRs

  • Qiong Lan
  • Jiangang Chen
  • Yuxin Guo
  • Tong Xie
  • Yating Fang
  • Xiaoye Jin
  • Wei Cui
  • Yongsong Zhou
  • Bofeng ZhuEmail author
Original Article


In the present study, we calculated the allelic frequencies and forensic descriptive parameters of Hui ethnic minority on the basis of 21 short tandem repeat (STR) loci aiming at understanding population structure better and enriching population genetic database. Bloodstain samples of 506 unrelated healthy Hui individuals in Xinjiang Uygur Autonomous Region were collected. Altogether 268 alleles were observed and the allelic frequencies ranged from 0.0010 to 0.5306. The combined power of discrimination and the cumulative probability of exclusion of the 21 STR loci in Hui ethnic minority were 0.9999999999999999999999998697 and 0.9999999968, respectively. Population data obtained manifested that the panel of 21 STR loci could provide robust genetic information for individual identification and paternity testing involved in forensic applications for Huis of Xinjiang Region. Furthermore, the present results of interpopulation differentiations, phylogenetic trees and principal component analysis which were conducted based on the overlapping 16 STR loci revealed that Hui group was genetically close to Xibe ethnic group and Han populations from different regions.


Hui ethnic minority STR GlobalFiler Population differentiation 



This work was supported by the National Natural Science Foundation of China (NSFC, Nos. 81525015, 81373248), GDUPS (2017).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Qiong Lan
    • 1
  • Jiangang Chen
    • 2
  • Yuxin Guo
    • 3
    • 4
  • Tong Xie
    • 1
  • Yating Fang
    • 1
  • Xiaoye Jin
    • 3
    • 4
  • Wei Cui
    • 3
    • 4
  • Yongsong Zhou
    • 1
  • Bofeng Zhu
    • 1
    • 3
    • 4
    Email author
  1. 1.Department of Forensic Genetics, School of Forensic MedicineSouthern Medical UniversityGuangzhouPeople’s Republic of China
  2. 2.Institute of Forensic ScienceMinistry of Public SecurityBeijingPeople’s Republic of China
  3. 3.Key laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of StomatologyXi’an Jiaotong UniversityXi’anPeople’s Republic of China
  4. 4.Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of StomatologyXi’an Jiaotong UniversityXi’anPeople’s Republic of China

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