Molecular Biology Reports

, Volume 44, Issue 5, pp 407–412 | Cite as

Sciatic nerve regeneration by transplantation of menstrual blood-derived stem cells

  • Saeed Farzamfar
  • Mahdi Naseri-Nosar
  • Alireza Ghanavatinejad
  • Ahmad Vaez
  • Amir Hassan Zarnani
  • Majid Salehi
Short Communication
First Online:
Received:
Accepted:

Abstract

This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via a neural guidance conduit, for peripheral nerve regeneration. The synthesized poly (ɛ-caprolactone)/Gelatin conduit, filled with collagen type I and seeded with 3 × 104 MenSCs, was implanted into a rat’s 10 mm sciatic nerve defect. The results of hot plate latency, sciatic functional index and weight-loss percentage of wet gastrocnemius muscle demonstrated that the MenSC transplantation had comparable nerve regeneration outcome to autograft, as the gold standard of nerve bridging. The transplantation of MenSCs via a synthetic conduit could ameliorate the functional recovery of sciatic nerve-injured rats which make them a potential candidate for cell therapy of peripheral nervous system disorders.

Keywords

Menstrual blood-derived stem cells Neural guidance conduit Peripheral nerve regeneration 
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Supplementary material

11033_2017_4124_MOESM1_ESM.docx (22 kb)
Supplementary material 1 (DOCX 21 KB)

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Saeed Farzamfar
    • 1
  • Mahdi Naseri-Nosar
    • 2
  • Alireza Ghanavatinejad
    • 3
  • Ahmad Vaez
    • 2
  • Amir Hassan Zarnani
    • 4
    • 5
  • Majid Salehi
    • 6
  1. 1.Department of Medical Nanotechnology, School of Advanced Technologies in MedicineTehran University of Medical SciencesTehranIran
  2. 2.Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in MedicineTehran University of Medical SciencesTehranIran
  3. 3.Department of Immunology, School of Public HealthTehran University of Medical SciencesTehranIran
  4. 4.Reproductive Immunology Research CenterAvicenna Research Institute, ACECRTehranIran
  5. 5.Immunology Research CenterIran University of Medical SciencesTehranIran
  6. 6.Department of Tissue Engineering, School of MedicineShahroud University of Medical SciencesShahroudIran

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