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Molecular Biology Reports

, Volume 43, Issue 7, pp 667–676 | Cite as

Chicken gga-miR-130a targets HOXA3 and MDFIC and inhibits Marek’s disease lymphoma cell proliferation and migration

  • Bo Han
  • Ling Lian
  • Xin Li
  • Chunfang Zhao
  • Lujiang Qu
  • Changjun Liu
  • Jiuzhou Song
  • Ning Yang
Original Article

Abstract

Marek’s disease (MD) is an infectious disease of chickens caused by MD virus (MDV), which is a herpesvirus that initiates tumor formation. Studies have indicated that microRNAs (miRNAs) are linked with the development of cancers or tumors. Previously, gga-miR-130a was discovered downregulated in MDV-infected tissues. Here, we aimed to explore the further function of gga-miR-130a in MD. The expression of gga-miR-130a in MDV-infected and uninfected spleens was detected by quantitative real-time PCR (qRT-PCR). Subsequently, proliferation and migration assays of MDV-transformed lymphoid cells (MSB1) were carried out by transfecting gga-miR-130a. The target genes of gga-miR-130a were predicted using TargetScan and miRDB and clustered through Gene Ontology analysis. The target genes were validated by western blot, qRT-PCR, and a dual luciferase reporter assay. Our results show that the expression of gga-miR-130a was reduced in MDV-infected spleens. Gga-miR-130a showed an inhibitory effect on MSB1 cell proliferation and migration. Two target genes, homeobox A3 (HOXA3) and MyoD family inhibitor domain containing (MDFIC), were predicted and clustered to cell proliferation. Results indicate that gga-miR-130a regulates HOXA3 and MDFIC at the protein level but not at the mRNA level. Moreover, the gga-miR-130a binding sites of two target genes have been confirmed. We conclude that gga-miR-130a can arrest MSB1 cell proliferation and migration, and target HOXA3 and MDFIC, which are both involved in the regulation of cell proliferation. Collectively, gga-miR-130a plays a critical role in the tumorigenesis associated with chicken MD.

Keywords

Chicken Marek’s disease gga-miR-130a Cell proliferation Cell migration HOXA3 MDFIC 

Notes

Acknowledgments

The work was supported in part by the National Natural Science Foundation of China (31320103905 and 31301957), the Program for Changjiang Scholars and Innovative Research in University of China (IRT1191), China Agriculture Research Systems (CARS-41), and Natural Science Foundation of Beijing, China (Grant No. 5154030).

Supplementary material

11033_2016_4002_MOESM1_ESM.xls (1.3 mb)
Supplementary material 1 (XLS 1372 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Bo Han
    • 1
  • Ling Lian
    • 1
  • Xin Li
    • 1
  • Chunfang Zhao
    • 1
  • Lujiang Qu
    • 1
  • Changjun Liu
    • 2
  • Jiuzhou Song
    • 3
  • Ning Yang
    • 1
  1. 1.Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina
  2. 2.Division of Avian Infectious DiseasesHarbin Veterinary Research Institute of Chinese Academy of Agricultural SciencesHarbinChina
  3. 3.Department of Animal & Avian SciencesUniversity of MarylandCollege ParkUSA

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