Molecular Biology Reports

, Volume 43, Issue 1, pp 11–16 | Cite as

Genotype/allelic combinations as potential predictors of myocardial infarction

  • Timur R. Nasibullin
  • Yanina R. Timasheva
  • Regina I. Sadikova
  • Ilsiyar A. Tuktarova
  • Vera V. Erdman
  • Irina E. Nikolaeva
  • Jan Sabo
  • Peter KruzliakEmail author
  • Olga E. Mustafina
Short Communication


In order to find new informative predictors of myocardial infarction, we performed an analysis of genotype frequencies of polymorphic markers of SELE (rs2076059, 3832T > C), SELP (rs6131, S290 N), SELL (rs1131498, F206L), ICAM1 (rs5498, K469E), VCAM1 (rs3917010, c.928 + 420A > C), PECAM1 (rs668, V125L), VEGFA (rs35569394, –2549(18)I/D), CCL2 (rs1024611, –2518A > G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c.303 + 30998A > G) genes in the group of Russian men with myocardial infarction (N = 315) and the control group of corresponding ethnicity, gender, and age (N = 286). Using Markov chain Monte-Carlo method (APSampler), we found genotype combinations associated with increased and decreased risk of myocardial infarction. The most significant associations were detected for PECAM1*V/V + DDAH1*C (OR = 4.17 CI 1.56–11.15 Pperm = 0.005) SELE*C + VEGFA*I + CCL2*G + VCAM1*A + NOS3*D (OR = 2.74 CI 1.66-4.52 Pperm = 2.09 × 10−5), and VEGFA*D/D + CCL2*A + DDAH1*C (OR = 0.44 CI 0.28-0.7 Pperm = 7.89 × 10−5) genotype combinations.


Myocardial infarction Risk prediction Genetic testing 



The study was supported with the equipment provided by USC “Complex equipment for the study of nucleic acids—KODINC”.

Compliance with ethical standards

Conflict of interest

Authors declare no conflict of interest.


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Timur R. Nasibullin
    • 1
  • Yanina R. Timasheva
    • 1
  • Regina I. Sadikova
    • 1
  • Ilsiyar A. Tuktarova
    • 1
  • Vera V. Erdman
    • 1
  • Irina E. Nikolaeva
    • 2
  • Jan Sabo
    • 3
  • Peter Kruzliak
    • 3
    • 4
    • 5
    Email author
  • Olga E. Mustafina
    • 1
  1. 1.Institute of Biochemistry and Genetics, Ufa Scientific CentreRussian Academy of SciencesUfaRussian Federation
  2. 2.Republic Centre for CardiologyUfaRussian Federation
  3. 3.Department of Medical Physics and Biophysics, Faculty of MedicinePavol Jozef Safarik UniversityKosiceSlovak Republic
  4. 4.2nd Department of Internal Medicine, Faculty of MedicineMasaryk UniversityBrnoCzech Republic
  5. 5.Department of Pharmacology and Toxicology, Faculty of PharmacyComenius UniversityBratislavaSlovak Republic

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