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Molecular Biology Reports

, Volume 41, Issue 12, pp 7729–7735 | Cite as

Keratin 19 expression correlates with poor prognosis in breast cancer

  • Nuzhat N. Kabir
  • Lars Rönnstrand
  • Julhash U. Kazi
Article

Abstract

Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression. Expression of TPD52, GATA3 and KRT18 was increased in KRT19 expressing patients. Furthermore, KRT19 expression was associated with ER up-regulation and Luminal B gene signatures, as well as a constitutive RAF1 signaling pathway. Finally, KRT19 expression correlated with poor overall survival. Taken together, our results suggest that KRT19 expression can be used as a prognostic marker.

Keywords

Cytokeratin 19 CK19 KRT19 Microarray 

Notes

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Nuzhat N. Kabir
    • 1
  • Lars Rönnstrand
    • 2
  • Julhash U. Kazi
    • 1
    • 2
  1. 1.Laboratory of Computational BiochemistryKN Biomedical Research InstituteBarisalBangladesh
  2. 2.Translational Cancer Research and Lund Stem Cell Center, Department of Laboratory MedicineLund UniversityLundSweden

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