Molecular Biology Reports

, Volume 41, Issue 11, pp 7381–7386

Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene

  • Mustafa Solak
  • Mujgan Ozdemir Erdogan
  • Saliha Handan Yildiz
  • Kagan Ucok
  • Seref Yuksel
  • Evrim Suna Arıkan Terzi
  • Ahmet Bestepe
Article

Abstract

The aim of this study is to investigate the genetic influence of polymorphisms in fat mass and obesity associated (FTO) gene on a sample of obese subjects and controls. Obesity is an epidemic all over the world. Several polymorphisms in the first intron of FTO gene have been associated with common forms of human obesity. In this research rs1421085 and rs9939609 polymorphisms of FTO gene were genotyped in 190 obese patients with a BMI ≥30 kg/m2 (Body Mass Index) and 97 healthy controls with a BMI of 18.5–24.9. Genotyping of SNPs was performed by real-time polymerase chain reaction. Body composition was established with bioelectric impedance analysis. Waist-to-hip ratio was determined for all participants. There were no significant differences (P > 0.05) between obese cases and controls in terms of genotype frequencies of rs1421085 and rs9939609 polymorphisms in our study. Also there were no significant correlations between genotypes and obesity related (anthropometric-body composition) parameters (P > 0.05).

Keywords

FTO Polymorphism Obesity BMI Body fat 

Supplementary material

11033_2014_3627_MOESM1_ESM.pdf (268 kb)
Supplementary material 1 (PDF 267 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Mustafa Solak
    • 1
  • Mujgan Ozdemir Erdogan
    • 1
  • Saliha Handan Yildiz
    • 1
  • Kagan Ucok
    • 2
  • Seref Yuksel
    • 3
  • Evrim Suna Arıkan Terzi
    • 1
  • Ahmet Bestepe
    • 4
  1. 1.Department of Medical Genetics, Faculty of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey
  2. 2.Department of Physiology, Faculty of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey
  3. 3.Department of Nephrology, Faculty of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey
  4. 4.Family Health Center No: 2AfyonkarahisarTurkey

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