Molecular Biology Reports

, Volume 41, Issue 1, pp 317–324 | Cite as

Association between polymorphism in TRAF1/C5 gene and risk of rheumatoid arthritis: a meta-analysis

  • Xingang Zhang
  • Wei Li
  • Xinpeng Zhang
  • Xiaoli Zhang
  • Li Jiang
  • Yun Guo
  • Xiaofei Wang


Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disease. Single nucleotide polymorphisms of tumor necrosis factor-receptor associated factor 1/complement component 5 (TRAF1/C5) gene are suspected to be associated with the risk of RA. This meta-analysis was performed to study the relationship between the polymorphism rs10818488 in TRAF1/C5 gene with RA. We retrieved the relevant articles from PubMed, EMBASE and the China National Knowledge Infrastructure databases. Odd ratios were calculated to assess the association between TRAF1/C5 rs10818488 polymorphism and RA risk. Meta-analyses were performed on the total data set and separately for the major ethnic groups and RF and ACAP status. All analyses were performed using the Stata software. Eight articles were included in the present analysis. Meta-analysis showed a weak association between TRAF1/C5 rs10818488 polymorphism and RA in all subjects (OR = 1.13, 95 % CI = 1.01–1.27, P heterogeneity < 0.001). Stratified analyses indicated that the TRAF1/C5 rs10818488 A allele was significantly associated with RA in Caucasians (OR = 1.29, 95 %CI = 1.14–1.47, P heterogeneity = 0.026), Asians (OR = 0.92, 95 %CI = 0.86–0.99, P heterogeneity = 0.378) and Africans (OR = 1.56, 95 %CI = 1.23–1.98, P heterogeneity = 0.876), also significantly in positive ACPA and positive RF patients versus controls (ORs were 1.20 and 1.25, 95 %CIs were 1.08–1.33 and 1.14–1.37, P values for heterogeneity were 0.215 and 0.133, respectively). Genetic polymorphism rs10818488 in TRAF1/C5 gene might be associated with RA susceptibility.


Rheumatiod arthritis Tumor necrosis factor-receptor associated factor 1/complement component 5 Single nucleotide polymorphism Meta-analysis 



The authors declare that they have no competing interests.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Xingang Zhang
    • 1
  • Wei Li
    • 2
  • Xinpeng Zhang
    • 3
  • Xiaoli Zhang
    • 1
  • Li Jiang
    • 1
  • Yun Guo
    • 1
  • Xiaofei Wang
    • 1
  1. 1.Department of RheumatologyShengjing Hospital of China Medical UniversityShenyangChina
  2. 2.Editorial Department of Chinese Pediatric Emergency MedicineShenyangChina
  3. 3.Department of NeurosurgeryThe Fourth People’s Hospital of Shenyang CityShenyangChina

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