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Molecular Biology Reports

, Volume 40, Issue 10, pp 5523–5530 | Cite as

HLA in Georgians (Caucasus) and their relationship with Eastern Mediterraneans

  • Diego Rey
  • Cristina Areces
  • Javier Alonso-Rubio
  • Mercedes Enríquez-de-Salamanca
  • Sedeka Abd-El-Fatah-Khalil
  • Nina Bendikuze
  • Mercedes Fernández-Honrado
  • Luz Barbolla
  • José Manuel Martín-Villa
  • Antonio Arnaiz-VillenaEmail author
Article

Abstract

HLA-A, -B, -DQB1, and –DRB1 typing has been performed in a sample of Georgian population (South Caucasus). Allele frequencies, neighbour joining and correspondence relatedness analyses and extended HLA haplotypes have been obtained with comparison with other Middle East and Mediterranean populations. Our Georgian sample tends to be genetically related in these analyses with Eastern Mediterraneans and Middle East people. This is important for future regional transplant programs, and Georgian HLA and disease epidemiology and pharmacogenomics.

Keywords

Caucasians Georgians Greeks HLA Pharmacogenomics Population genetics 

Notes

Acknowledgments

This work was supported in part by grants from the Spanish Ministry of Health (FISS PI080838 and PI11/00807) and three different Mutua Madrileña Automovilista grants.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Diego Rey
    • 1
  • Cristina Areces
    • 1
  • Javier Alonso-Rubio
    • 1
  • Mercedes Enríquez-de-Salamanca
    • 1
  • Sedeka Abd-El-Fatah-Khalil
    • 2
  • Nina Bendikuze
    • 3
  • Mercedes Fernández-Honrado
    • 2
  • Luz Barbolla
    • 2
  • José Manuel Martín-Villa
    • 1
  • Antonio Arnaiz-Villena
    • 1
    Email author
  1. 1.Department of ImmunologySchool of Medicine, Madrid Regional Blood Center, University ComplutenseMadridSpain
  2. 2.Department of HaematologyMadrid Regional Blood CenterMadridSpain
  3. 3.Institute for Clinical and Experimental MedicinePragueCzech Republic

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