Molecular Biology Reports

, Volume 40, Issue 4, pp 3065–3071 | Cite as

Association of endothelial nitric oxide synthase gene polymorphisms with classical risk factors in development of premature coronary artery disease

Article

Abstract

Genetic polymorphism of the endothelial nitric oxide synthase (eNOS) affects the pathogenesis of atherosclerosis and associated with premature coronary artery disease (PCAD). We aimed to explore the association between Glu298Asp polymorphism of the eNOS gene and premature CAD in Egyptians, and the possible interaction between this polymorphism and other risk factors. The study population consisted of 116 patients with PCAD, and 119 controls. Glu298Asp polymorphism (rs1799983) of the eNOS gene was analyzed by polymerase chain reaction (PCR). We found that the TT genotype of the eNOS gene increased the risk of PCAD by 2.6. Hypertension, diabetes, smoking, total cholesterol, triglycerides, LDLc, HDLc and TT genotype of the eNOS gene were independent risk factors for the development of PCAD. We conclude that, the TT genotype of Glu298Asp polymorphism of eNOS gene is an independent risk factor of PCAD in Egyptians. The association of smoking, obesity, dyslipidemia and/or metabolic syndrome with the TT genotype increased the risk of the development of PCAD.

Keywords

eNOS Genetic polymorphism Premature CAD 

Notes

Acknowledgments

This study was funded with the support of academic research in Zagazig University Projects, Post Graduate & Research Affairs, Zagazig University, Zagazig, Egypt.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Cardiology DepartmentFaculty of Medicine, Zagazig UniversityZagazigEgypt
  2. 2.Medical Biochemistry DepartmentFaculty of Medicine, Zagazig UniversityZagazigEgypt

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