Molecular Biology Reports

, Volume 40, Issue 3, pp 2253–2261 | Cite as

Preeclampsia and ABO blood groups: a systematic review and meta-analysis

  • Patricia Nessralla Alpoim
  • Melina de Barros Pinheiro
  • Daniela Rezende Garcia Junqueira
  • Leticia Gonçalves Freitas
  • Maria das Graças Carvalho
  • Ana Paula Salles Moura Fernandes
  • Flávia Komatsuzaki
  • Karina Braga Gomes
  • Luci Maria Sant’Ana Dusse


Preeclampsia (PE) is a multifactorial pregnancy-specific syndrome which represents one of the leading causes of maternal mortality worldwide. Inherited thrombophilia have been investigated as risk factor for the development of PE and it is currently known that ABO blood group may impact haemostatic balance, having the non-O blood groups (A, B or AB) subjects increased risk for thrombus formation, as compared to those of group O. We performed a systematic review of the literature for published studies investigating whether ABO blood groups could influence PE developing. A sensitive search of four databases identified 45 unique titles. The retrieved papers were assessed independently by authors and a rigorous process of selection and data extract was conduct. Methodological quality of the included studies was also evaluated. Two studies met eligibility criteria. As a main finding of our systematic review, an association between the AB blood group and the occurrence of PE was detected based on two original studies. Considering the role of ABO blood groups on the hemostatic process and thrombus formation, special attention should be given to pregnant patients carrying the AB blood group in order to prevent the syndrome and improve prognosis.


Preeclampsia ABO blood-group system Risk factors Systematic review 



This work received grants from MCT/CT-Saúde and Decit/SCTIE/MS through the National Counsel of Technological, CNPq and FAPEMIG. APSMF, DRGJ, MGC and LMSD are grateful to the National Counsel of Technological and Scientific Development of Brazil (CNPq) for received research fellowship.

Conflict of interest

All authors disclose no financial or personal relationship with other people or organizations that could inappropriately influence their work.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Patricia Nessralla Alpoim
    • 1
  • Melina de Barros Pinheiro
    • 1
  • Daniela Rezende Garcia Junqueira
    • 1
    • 2
  • Leticia Gonçalves Freitas
    • 1
  • Maria das Graças Carvalho
    • 1
  • Ana Paula Salles Moura Fernandes
    • 1
  • Flávia Komatsuzaki
    • 1
  • Karina Braga Gomes
    • 1
  • Luci Maria Sant’Ana Dusse
    • 1
  1. 1.Department of Clinical and Toxicological Analyses, School of PharmacyFederal University of Minas GeraisBelo HorizonteBrazil
  2. 2.Centre of Drug Studies (Cemed), Department of Social Pharmacy, School of PharmacyFederal University of Minas GeraisBelo HorizonteBrazil

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