Molecular Biology Reports

, Volume 40, Issue 2, pp 941–948

Association of RANTES and MBL gene polymorphisms with systemic lupus erythematosus: a meta-analysis

  • Wang-Dong Xu
  • Hui Peng
  • Mo Zhou
  • Min Zhang
  • Bao-Zhu Li
  • Hai-Feng Pan
  • Dong-Qing Ye
Article

Abstract

The RANTES (regulated on activation normal T cell expressed and secreted) and MBL (mannose binding lectin) single-nucleotide polymorphisms have been repeatedly associated with systemic lupus erythematosus (SLE), but the findings are not consistent across studies. The aim of this study was to determine whether the functional RANTES-28, -403 and MBL2 A/O polymorphisms confer susceptibility to SLE in multiple ethnic populations. A meta-analysis was conducted (allelic contrast, the additive model, the dominant model and the recessive model) on RANTES with seven studies (four studies for RANTES-28: three Asian and one American studies; three studies for RANTES-403: two Asian and one European studies), MBL with eight studies (five European and three American studies). OR is used as a measure of the effect of the association in a fixed/random effects model. The meta-analysis indicated that none of the two polymorphisms in gene of the RANTES showed any significant association with SLE risk, respectively, except for the recessive model (OR = 1.24, 95 % CI: 1.01–1.52, P = 0.04) in all study subjects combined with the two polymorphisms. According to the MBL2 A/O polymorphism, the results indicated a significant association between the polymorphism and SLE in allelic contrast (OR = 0.83, 95 % CI: 0.73–0.93, P = 0.002). While stratified by ethnicity in European, no significant association was found. In summary, the present study suggests that the RANTES-28, -403 polymorphisms do not associate with SLE, but the MBL2 A/O polymorphism might associate with SLE.

Keywords

Regulated on activation normal T cell expressed and secreted Mannose binding lectin Systemic lupus erythematosus Polymorphism Meta-analysis 

References

  1. 1.
    Vyse TJ, Kotzin BL (1996) Genetic basis of systemic lupus erythematosus. Curr Opin Immunol 8:843–851PubMedCrossRefGoogle Scholar
  2. 2.
    Moser KL, Kelly JA, Lessard CJ, Harley JB (2009) Recent insights into the genetic basis of systemic lupus erythematosus. Genes Immun 10:373–379PubMedCrossRefGoogle Scholar
  3. 3.
    Sánchez E, Sabio JM, Callejas JL, de Ramón E, Garcia-Portales R, García-Hernández FJ, Jiménez-Alonso J, González-Escribano MF, Martín J, Koeleman BP (2006) Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. BMC Med Genet 7:48PubMedCrossRefGoogle Scholar
  4. 4.
    Lu MM, Wang J, Pan HF, Chen GM, Li J, Cen H, Feng CC, Ye DQ (2012) Increased serum RANTES in patients with systemic lupus erythematosus. Rheumatol Int 32:1231–1233PubMedCrossRefGoogle Scholar
  5. 5.
    Lima G, Soto-Vega E, Atisha-Fregoso Y, Sánchez-Guerrero J, Vallejo M, Vargas-Alarcón G, Llorente L (2007) MCP-1, RANTES, and SDF-1 polymorphisms in Mexican patients with systemic lupus erythematosus. Hum Immunol 68:980–985PubMedCrossRefGoogle Scholar
  6. 6.
    Chan RW, Lai FM, Li EK, Tam LS, Chow KM, Li PK, Szeto CC (2006) Messenger RNA expression of RANTES in the urinary sediment of patients with lupus nephritis. Nephrology (Carlton) 11:219–225CrossRefGoogle Scholar
  7. 7.
    Eriksson C, Eneslätt K, Ivanoff J, Rantapää-Dahlqvist S, Sundqvist KG (2003) Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus. Lupus 12:766–774PubMedCrossRefGoogle Scholar
  8. 8.
    Kaneko H, Ogasawara H, Naito T, Akimoto H, Lee S, Hishikawa T, Sekigawa I, Tokano Y, Takasaki Y, Hirose SI, Hashimoto H (1999) Circulating levels of beta-chemokines in systemic lupus erythematosus. J Rheumatol 26:568–573PubMedGoogle Scholar
  9. 9.
    Lian LH, Kee BP, Ng HL, Chua KH (2011) Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population. Genet Mol Res 10:2841–2850PubMedCrossRefGoogle Scholar
  10. 10.
    Ye DQ, Yang SG, Li XP, Hu YS, Yin J, Zhang GQ, Liu HH, Wang Q, Zhang KC, Dong MX, Zhang XJ (2005) Polymorphisms in the promoter region of RANTES in Han Chinese and their relationship with systemic lupus erythematosus. Arch Dermatol Res 297:108–113PubMedCrossRefGoogle Scholar
  11. 11.
    Lee YH, Witte T, Momot T, Schmidt RE, Kaufman KM, Harley JB, Sestak AL (2005) The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus. Arthritis Rheum 52:3966–3974PubMedCrossRefGoogle Scholar
  12. 12.
    García-Laorden MI, Rúa-Figueroa I, Pérez-Aciego P, Rodríguez-Pérez JC, Citores MJ, Alamo F, Erausquin C, Rodríguez-Gallego C (2003) Mannose binding lectin polymorphisms as a disease-modulating factor in women with systemic lupus erythematosus from Canary Islands, Spain. J Rheumatol 30:740–746PubMedGoogle Scholar
  13. 13.
    Madsen HO, Garred P, Kurtzhals JA, Lamm LU, Ryder LP, Thiel S, Svejgaard A (1994) A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics 40:37–44PubMedCrossRefGoogle Scholar
  14. 14.
    Jakab L, Laki J, Sallai K, Temesszentandrási G, Pozsonyi T, Kalabay L, Varga L, Gombos T, Blaskó B, Bíró A, Madsen HO, Radics J, Gergely P, Füst G, Czirják L, Garred P, Fekete B (2007) Association between early onset and organ manifestations of systemic lupus erythematosus (SLE) and a down-regulating promoter polymorphism in the MBL2 gene. Clin Immunol 125:230–236PubMedCrossRefGoogle Scholar
  15. 15.
    Garred P, Larsen F, Madsen HO, Koch C (2003) Mannose-binding lectin deficiency-revisited. Mol Immunol 40:73–84PubMedCrossRefGoogle Scholar
  16. 16.
    Sandrin-Garcia P, Brandão LA, Coelho AV, Guimarães RL, Pancoto JA, Segat L, Donadi EA, de Lima-Filho JL, Crovella S (2011) Mannose binding lectin gene (MBL2) functional polymorphisms are associated with systemic lupus erythematosus in southern Brazilians. Hum Immunol 72:516–521PubMedCrossRefGoogle Scholar
  17. 17.
    Monticielo OA, Mucenic T, Xavier RM, Brenol JC, Chies JA (2008) The role of mannose-binding lectin in systemic lupus erythematosus. Clin Rheumatol 27:413–419PubMedCrossRefGoogle Scholar
  18. 18.
    Yang Z, Liang Y, Qin B, Li C, Zhong R (2012) TLR9 polymorphisms and systemic lupus erythematosus risk in Asians: a meta-analysis study. Cytokine 57:282–289PubMedCrossRefGoogle Scholar
  19. 19.
    Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634PubMedCrossRefGoogle Scholar
  20. 20.
    Lee YH, Nath SK (2005) Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis. Hum Gene 118:434–443CrossRefGoogle Scholar
  21. 21.
    Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA, Ferreira RC, Pant PV, Ballinger DG, Kosoy R, Demirci FY, Kamboh MI, Kao AH, Tian C, Gunnarsson I, Bengtsson AA, Rantapää-Dahlqvist S, Petri M, Manzi S, Seldin MF, Rönnblom L, Syvänen AC, Criswell LA, Gregersen PK, Behrens TW (2008) Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 358:900–909PubMedCrossRefGoogle Scholar
  22. 22.
    Honda K, Yanai H, Takaoka A, Taniguchi T (2005) Regulation of the type I IFN induction: a current view. Int Immunol 17:1367–1378PubMedCrossRefGoogle Scholar
  23. 23.
    Zhang YG, Huang J, Zhang J, Li XB, He C, Xiao YL, Tian C, Wan H, Zhao YL, Tsewang YG, Fan H (2010) RANTES gene polymorphisms and asthma risk: a meta-analysis. Arch Med Res 41:50–58PubMedCrossRefGoogle Scholar
  24. 24.
    Garred P, Voss A, Madsen HO, Junker P (2001) Association of mannose-binding lectin gene variation with disease severity and infections in a population-based cohort of systemic lupus erythematosus patients. Genes Immun 2:442–450PubMedCrossRefGoogle Scholar
  25. 25.
    Monticielo OA, Chies JA, Mucenic T, Rucatti GG, Júnior JM, da Silva GK, Glesse N, dos Santos BP, Brenol JC, Xavier RM (2010) Mannose-binding lectin gene polymorphisms in Brazilian patients with systemic lupus erythematosus. Lupus 19:280–287PubMedCrossRefGoogle Scholar
  26. 26.
    Piao W, Liu CC, Kao AH, Manzi S, Vogt MT, Ruffing MJ, Ahearn JM (2007) Mannose-binding lectin is a disease-modifying factor in North American patients with systemic lupus erythematosus. J Rheumatol 34:1506–1513PubMedGoogle Scholar
  27. 27.
    Liao CH, Yao TC, Chung HT, See LC, Kuo ML, Huang JL (2004) Polymorphisms in the promoter region of RANTES and the regulatory region of monocyte chemoattractant protein-1 among Chinese children with systemic lupus erythematosus. J Rheumatol 31:2062–2067PubMedGoogle Scholar
  28. 28.
    Garred P, Madsen HO, Halberg P, Petersen J, Kronborg G, Svejgaard A, Andersen V, Jacobsen S (1999) Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus. Arthritis Rheum 42:2145–2152PubMedCrossRefGoogle Scholar
  29. 29.
    Pan HF, Leng RX, Ye DQ (2011) Lack of association of Interleukin-18 gene promoter -607A/C polymorphism with susceptibility to autoimmune diseases: a meta-analysis. Lupus 20:945–951PubMedCrossRefGoogle Scholar
  30. 30.
    Tian S, Li J, Wang L, Liu T, Liu H, Cheng G, Liu D, Deng Y, Gou R, Wan Y, Jia J, Chen C (2007) Urinary levels of RANTES and M-CSF are predictors of lupus nephritis flare. Inflamm Res 56:304–310PubMedCrossRefGoogle Scholar
  31. 31.
    Cockwell P, Calderwood JW, Brooks CJ, Chakravorty SJ, Savage CO (2002) Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines. Nephrol Dial Transplant 17:734–744PubMedCrossRefGoogle Scholar
  32. 32.
    Furuichi K, Wada T, Sakai N, Iwata Y, Yoshimoto K, Shimizu M, Kobayashi K, Takasawa K, Kida H, Takeda SI, Mukaida N, Matsushima K, Yokoyama H (2000) Distinct expression of CCR1 and CCR5 in glomerular and inter-stitial lesions of human glomerular diseases. Am J Nephrol 20:291–299PubMedCrossRefGoogle Scholar
  33. 33.
    Vilá LM, Molina MJ, Mayor AM, Cruz JJ, Ríos-Olivares E, Ríos Z (2007) Association of serum MIP-1 alpha, MIP-1 beta, and RANTES with clinical manifestations, disease activity, and damage accrual in systemic lupus erythematosus. Clin Rheumatol 26:718–722PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Wang-Dong Xu
    • 1
    • 2
  • Hui Peng
    • 1
    • 2
  • Mo Zhou
    • 1
    • 2
  • Min Zhang
    • 1
    • 2
  • Bao-Zhu Li
    • 1
    • 2
  • Hai-Feng Pan
    • 1
    • 2
  • Dong-Qing Ye
    • 1
    • 2
  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiPeople’s Republic of China
  2. 2.Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical UniversityHefeiPeople’s Republic of China

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