APE1 Asp148Glu gene polymorphism and bladder cancer risk: a meta-analysis
- 324 Downloads
Published data regarding the association between the apurinic/apyrimidinic endonuclease 1 (APE1) Asp148Glu polymorphism and bladder cancer risk showed inconclusive results. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, Elsevier and Springer for relevant articles with a time limit of Jan. 2012. The strength of association between APE1 Asp148Glu polymorphism and bladder cancer risk was assessed by odds ratio (OR) with the corresponding 95 % confidence interval (95 % CI) using the software STATA(version10.0).A total of 11 case–control studies including 4,292 cases and 4,761 controls based on the search criteria were included for analysis. Overall, for GG versus TT, the pooled OR was 0.952 (95 % CI = 0.778–1.166), for the the G allele carriers (TG + GG) versus homozygote TT, the pooled OR was 0.984 (95 % CI = 0.897–1.078). In the stratified analysis by ethnicity, significantly risks were not found among Asians for GG versus TT (OR = 0.469; 95 % CI = 0.162–1.357) nor (TG + GG) versus TT (OR = 0.921, 95 % CI = 0.742–1.143). Similarly, for non-Asians, significantly risks were also not found for GG versus TT (OR = 0.992; 95 % CI = 0.861–1.144) nor (TG + GG) versus TT (OR = 1.010, 95 % CI = 0.897–1.137). This meta-analysis suggested that the APE1 T1349G (Asp148Glu) polymorphism was not associated with bladder cancer risk among Asians nor non-Asians.
KeywordsMeta-analysis Bladder cancer APE1 Asp148Glu
- 15.Mittal RD, Mandal RK, Gangwar R (2011) Base excision repair pathway genes polymorphism in prostate and bladder cancer risk in North Indian population. Mech Ageing Dev. [Epub ahead of print]Google Scholar
- 27.Jiang DK, Ren WH, Yao L, Wang WZ, Peng B, Yu L(2010) Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder cancer risk. Urology. 76(3):765 e1–7Google Scholar
- 28.Li F, Li C, Jiang Z, Ma N, Gao X(2011) XRCC3 T241 M polymorphism and bladder cancer risk: a meta-analysis. Urology. 77: 511 e1–5Google Scholar
- 31.Friedberg EC (2003) DNA damage and repair. Nature 421:436–440Google Scholar