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Molecular Biology Reports

, Volume 39, Issue 10, pp 9405–9414 | Cite as

Quantitative assessment of the associations between four polymorphisms (FokI, ApaI, BsmI, TaqI) of vitamin D receptor gene and risk of diabetes mellitus

  • Qijuan Wang
  • Bo Xi
  • Kathleen Heather Reilly
  • Man Liu
  • Maosun FuEmail author
Article

Abstract

The vitamin D receptor (VDR) gene polymorphisms have been suggested to be involved in the development of diabetes mellitus, including type 1 diabetes (T1DM) and type 2 diabetes (T2DM). However, the results have been inconsistent. In this study, we performed a meta-analysis to investigate the associations. Literature was retrieved from PubMed, ISI Web of Science and Chinese databases. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated using a random or fixed effect model. 79 studies (FokI: 22 studies; BsmI: 25 studies; ApaI: 17 studies; TaqI: 15 studies) on T1DM and 44 studies (FokI: 10 studies; BsmI: 10 studies; ApaI: 14 studies; TaqI: 10 studies) on T2DM were included. The results indicated that BsmI polymorphism was associated with an increased risk of T1DM (B vs. b: OR 1.31, 95 % CI 1.10–1.55, P = 0.002), especially in East Asians (B vs. b: OR 2.57, 95 % CI: 1.55–4.24, P < 0.001); FokI polymorphism was associated with an increased risk of T2DM (f vs. F: OR 1.30, 95 % CI: 1.17–1.45, P < 0.001), especially in East Asians (f vs. F: OR 1.36, 95 % CI: 1.21–1.54, P < 0.001). However, no significant association was observed between ApaI or TaqI polymorphism and diabetes risk with the exception of significant association between ApaI polymorphism and T1DM risk in East Asians. Thus, the authors found BsmI polymorphism in the VDR gene may increase the risk of T1DM in East Asians and the FokI polymorphism may increase the risk of T2DM in East Asians.

Keywords

Vitamin D receptor Diabetes mellitus Genetic polymorphism Meta analysis 

Notes

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

11033_2012_1805_MOESM1_ESM.docx (42 kb)
Supplementary material 1 (DOCX 41 kb)
11033_2012_1805_MOESM2_ESM.tif (1.5 mb)
Supplementary Fig. 1. Meta-analysis of the association between FokI polymorphism in the VDR gene and type 1 diabetes (f vs. F) (TIFF 1579 kb)
11033_2012_1805_MOESM3_ESM.tif (1.7 mb)
Supplementary Fig. 2. Meta-analysis of the association between ApaI polymorphism in the VDR gene and type 1 diabetes (a vs. A) (TIFF 1703 kb)
11033_2012_1805_MOESM4_ESM.tif (1.8 mb)
Supplementary Fig. 3. Meta-analysis of the association between TaqI polymorphism in the VDR gene and type 1 diabetes (t vs. T) (TIFF 1794 kb)
11033_2012_1805_MOESM5_ESM.tif (1.6 mb)
Supplementary Fig. 4. Meta-analysis of the association between BsmI polymorphism in the VDR gene and type 2 diabetes (B vs. b) (TIFF 1672 kb)
11033_2012_1805_MOESM6_ESM.tif (1.7 mb)
Supplementary Fig. 5. Meta-analysis of the association between ApaI polymorphism in the VDR gene and type 2 diabetes (a vs. A) (TIFF 1767 kb)
11033_2012_1805_MOESM7_ESM.tif (1.8 mb)
Supplementary Fig. 6. Meta-analysis of the association between TaqI polymorphism in the VDR gene and type 2 diabetes (t vs. T) (TIFF 1839 kb)

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Qijuan Wang
    • 1
  • Bo Xi
    • 1
  • Kathleen Heather Reilly
    • 2
  • Man Liu
    • 1
  • Maosun Fu
    • 1
    Email author
  1. 1.Department of Maternal and Child Health Care, School of Public HealthShandong UniversityJinanChina
  2. 2.Tulane University Health Sciences Center, School of Public Health and Tropical MedicineNew OrleansUSA

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