Molecular Biology Reports

, Volume 39, Issue 10, pp 9319–9329

Association of the IL-10 polymorphisms and periodontitis: a meta-analysis

  • C. M. Albuquerque
  • A. J. Cortinhas
  • F. J. Morinha
  • J. C. Leitão
  • C. A. Viegas
  • E. M. Bastos
Article

Abstract

No clear consensus has been reached regarding the association of IL-10 polymorphisms and periodontitis. Therefore, we performed a meta-analysis of case–control studies and a systemic review in an effort to systematically summarize the existing knowledge. Studies were identified by searching PubMed database until December 2011. IL-10 −1082 (−1087) A>G, −819 (−824) C>T and −592 (−597) C>A polymorphisms were included in the present meta-analysis. We calculated the specific odds ratios along with their 95 % confidence intervals to compare the distribution of alleles and genotypes between cases and controls. An additive “per-allele” model (major allele vs. minor allele) was performed, and dominant and recessive models were also considered. The random-effects model was applied for the analysis. Cumulative analysis was also performed. Heterogeneity and publication bias were assessed. Nine case–control studies involving 841 periodontitis cases (644 chronic periodontitis and 197 aggressive periodontitis cases) and 748 controls were included. We found statistically significant association of IL-10 −819 (−824) C>T and IL-10 −592 (−597) C>A polymorphisms in Caucasians. The IL-10 −819 (−824) T and −592 (−597) A alleles may confer a relative increase in the risk for chronic periodontitis in Caucasians. Future studies may be important to reinforce these findings.

Keywords

Interleukin-10 Meta-analysis Periodontitis Polymorphism 

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • C. M. Albuquerque
    • 1
    • 2
  • A. J. Cortinhas
    • 3
  • F. J. Morinha
    • 1
    • 4
  • J. C. Leitão
    • 3
  • C. A. Viegas
    • 2
    • 5
  • E. M. Bastos
    • 1
    • 6
  1. 1.Centre of Genetics and BiotechnologyUniversity of Trás-os-Montes and Alto Douro, Institute for Biotechnology and Bioengineering (CGB-UTAD/IBB)Vila RealPortugal
  2. 2.Department of Veterinary Sciences, Agricultural and Veterinary Sciences SchoolUniversity of Trás-os-Montes e Alto DouroVila RealPortugal
  3. 3.Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD)University of Trás-os-Montes and Alto DouroVila RealPortugal
  4. 4.Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB)University of Trás-os-Montes and Alto DouroVila RealPortugal
  5. 5.3B’s Research Group: Biomaterials, Biodegradables and Biomimetics, Department of Polymer EngineeringUniversity of MinhoTaipas, GuimarãesPortugal
  6. 6.Department of Genetics and Biotechnology, Life and Ambient Sciences SchoolUniversity of Trás-os-Montes e Alto DouroVila RealPortugal

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