Molecular Biology Reports

, Volume 39, Issue 5, pp 5709–5717

Association between vitamin D receptor gene polymorphisms and bone mineral density in Chinese women

Article

Abstract

Vitamin D receptor (VDR) is implicated in the regulation of bone mineral density (BMD). In this study, we performed a meta-analysis to evaluate the association between the VDRBsmI (rs1544410) and ApaI (rs7975232) polymorphisms and BMD in Chinese women. Literature was retrieved from PubMed and other databases. The studies on the association between VDRBsmI and ApaI genotypes and BMD at the lumbar spine, the femoral neck, the trochanter or the Ward’s triangle in Han Chinese women were included in this meta-analysis. Pooled BMD differences and 95% confidence intervals (CIs) were calculated using random- or fixed- effects model. Twenty-five eligible studies, which included 4,075 Chinese women, were identified. No significant difference was observed for either genotype when the meta-analysis was limited to premenopausal women. In postmenopausal women, BMD differences were significant for BB vs. Bb [−0.029 (95% CI −0.056, −0.002) g/m2, P = 0.037] at the femoral neck, AA vs. Aa [−0.029 (95% CI −0.051, −0.006) g/m2, P = 0.012] at the lumbar spine, and Aa vs. aa [0.022(95% CI 0.011, 0.033) g/m2, P = 0.000] at the trochanter. These results suggest a modest but statistically significant association between VDR BsmI and ApaI polymorphisms and BMD in Chinese postmenopausal women, with higher BMD in heterozygous subjects. More epidemiological and mechanistic studies are needed to further investigate the role of VDR gene polymorphisms in regulating BMD and osteoporosis in the future.

Keywords

Bone mineral density Chinese Women Vitamin D receptor Polymorphism Meta-analysis 

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© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Department of Orthopaedics, Xiangya HospitalCentral South UniversityChangshaChina
  2. 2.Department of Maternal and Child Health Care, School of Public HealthShandong UniversityJinanChina
  3. 3.Baylor College of Medicine and The University of Texas M. D. Anderson Cancer CenterHoustonUSA

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