Molecular Biology Reports

, Volume 39, Issue 5, pp 5401–5407 | Cite as

Interleukin 1 beta −511 C/T gene polymorphism and susceptibility to febrile seizures: a meta-analysis

  • Zhen-Qiang Wu
  • Liang Sun
  • Ye-Huan Sun
  • Cizao Ren
  • Yu-Hong Jiang
  • Xiao-Ling Lv


One previous meta-analysis found no evidence that interleukin 1 beta (IL-1β) −511 gene polymorphism was associated with febrile seizures (FS) by pooling a limited number of studies. However, it is necessary for the meta-analysis to reevaluate the relationship with more recent findings. Electronic databases were systematically searched for studies published before June 2011. Pooled odds ratios (OR) and 95% confidence interval (CI) were estimated by means of a genetic model free approach. Subgroup and sensitivity analyses were also performed. All statistical analyses were conducted using Stata 9.0. A total of eight studies, 728 FS cases and 1,223 controls, met the selection criteria. The results show a significant association between IL-1β −511 C/T gene polymorphism and FS (recessive genetic model TT vs. CC + CT: OR = 1.361, 95% CI: 1.065–1.738, P = 0.014). Subgroup analyses show a significant association in Asia (OR = 1.394, 95% CI: 1.005–1.935, P = 0.047), but not in Europe (OR = 1.387, 95% CI: 0.750–2.565, P = 0.298). IL-1β −511 C/T gene polymorphism may play a role in susceptibility to FS, especially in Asia. Geographic differences may be a critical factor in the risk of FS.


Interleukin 1 beta Gene Polymorphism Febrile seizures Meta-analysis 


Conflict of interest

The authors declare no conflicts of interest.


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Zhen-Qiang Wu
    • 1
  • Liang Sun
    • 1
  • Ye-Huan Sun
    • 1
  • Cizao Ren
    • 2
  • Yu-Hong Jiang
    • 1
  • Xiao-Ling Lv
    • 1
  1. 1.Department of Epidemiology and Statistics, School of Public HealthAnhui Medical UniversityHefeiChina
  2. 2.Bureau of EpidemiologyFlorida Department of HealthTallahasseeUSA

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