Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN
- 318 Downloads
Genetic associations of fatty acid composition with exonic single nucleotide polymorphisms (SNPs) in the gene encoding fatty acid synthase (FASN) were examined using 513 Korean cattle. All five individual SNPs of g.12870 T>C, g.13126 T>C, g.15532 C>A, g.16907 T>C and g.17924 G>A were associated with a variety of fatty acid compositions and further with marbling score (P < 0.05). Their genotypes of CC, TT, AA, TT, and GG were associated with increased monounsaturated fatty acids and with decreased saturated fatty acids (P < 0.05). The genotypes at all the SNPs also increased marbling score (P < 0.05). Further genetic associations with fatty acid composition suggested that homozygous genotype with the haplotype of ATG at g.15532, g.16907, and g.17924 in a linkage disequilibrium block increased monounsaturated fatty acids and marbling score (P < 0.05). We concluded that the five exonic SNPs of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents. Their genotypes of CC, TT, AA, TT, and GG and haplotype of ATG at g.15532, g.16907, and g.17924 were recommended for genetic improvement of beef quality.
KeywordsBeef flavor Fatty acid composition Genetic association Unsaturated fatty acid
This work was supported by a grant from Next-Generation BioGreen 21 Program, Rural Development Administration, Republic of Korea (Grant No. PJ008135).
- 1.Melton SL, Amiri M, Davis GW, Backus WR (1982) Flavor and chemical characteristics of ground beef from grass-, forage-grain- and grain-finished steers. J Anim Sci 55:77–87Google Scholar
- 11.Bhuiyan MSA, Yu SL, Yoon D, Cho YM, Park EW, Kim NK, Kim KS, Lee JH (2009) DNA polymorphisms in SREBF1 and FASN genes affect fatty acid composition in Korean cattle (Hanwoo). Asian-Aust J Anim Sci 22:765–773Google Scholar
- 12.Ryu J, Kim Y, Kim C, Kim J, Lee C (2011) Association of bovine carcass phenotypes with genes in an adaptive thermogenesis pathway. Mol Biol Rep. doi: 10.1007/s11033-011-0880-5