Molecular Biology Reports

, Volume 39, Issue 4, pp 4083–4090 | Cite as

Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN

  • Dongyep Oh
  • Yoonseok Lee
  • Boomi La
  • Jungsou Yeo
  • Euiryong Chung
  • Younyoung Kim
  • Chaeyoung LeeEmail author


Genetic associations of fatty acid composition with exonic single nucleotide polymorphisms (SNPs) in the gene encoding fatty acid synthase (FASN) were examined using 513 Korean cattle. All five individual SNPs of g.12870 T>C, g.13126 T>C, g.15532 C>A, g.16907 T>C and g.17924 G>A were associated with a variety of fatty acid compositions and further with marbling score (P < 0.05). Their genotypes of CC, TT, AA, TT, and GG were associated with increased monounsaturated fatty acids and with decreased saturated fatty acids (P < 0.05). The genotypes at all the SNPs also increased marbling score (P < 0.05). Further genetic associations with fatty acid composition suggested that homozygous genotype with the haplotype of ATG at g.15532, g.16907, and g.17924 in a linkage disequilibrium block increased monounsaturated fatty acids and marbling score (P < 0.05). We concluded that the five exonic SNPs of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents. Their genotypes of CC, TT, AA, TT, and GG and haplotype of ATG at g.15532, g.16907, and g.17924 were recommended for genetic improvement of beef quality.


Beef flavor Fatty acid composition Genetic association Unsaturated fatty acid 



This work was supported by a grant from Next-Generation BioGreen 21 Program, Rural Development Administration, Republic of Korea (Grant No. PJ008135).

Supplementary material

11033_2011_1190_MOESM1_ESM.doc (125 kb)
Supplementary material 1 (DOC 125 kb)


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Dongyep Oh
    • 1
  • Yoonseok Lee
    • 2
  • Boomi La
    • 1
  • Jungsou Yeo
    • 1
  • Euiryong Chung
    • 3
  • Younyoung Kim
    • 4
  • Chaeyoung Lee
    • 4
    Email author
  1. 1.School of BiotechnologyYeungnam UniversityGyeongsanSouth Korea
  2. 2.Institute of Charmpoom HanwooGyeongsanSouth Korea
  3. 3.Division of Animal Science and ResourcesSangji UniversityWonjuSouth Korea
  4. 4.School of Systems Biomedical ScienceSoongsil UniversitySeoulSouth Korea

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