Molecular Biology Reports

, Volume 39, Issue 3, pp 2313–2319 | Cite as

A common variant in the adiponectin gene and polycystic ovary syndrome risk

  • Fariba Ranjzad
  • Touraj Mahmoudi
  • Atena Irani Shemirani
  • Aidin Mahban
  • Abdolrahim Nikzamir
  • Mohsen Vahedi
  • Mahnaz Ashrafi
  • Hamid Gourabi


In this study, we explored whether polymorphisms in insulin receptor (INSR), adiponectin (ADIPOQ), parathyroid hormone (PTH), and vitamin D receptor (VDR) genes are associated with polycystic ovary syndrome (PCOS). A total of 362 subjects, including 181 women with PCOS and 181 controls were enrolled in this case-control study. Two SNPs (rs2059806 and rs1799817) in the INSR gene, two SNPs (rs2241766 and rs1501299) in the ADIPOQ gene, one SNP (rs6256) in the PTH gene, and one SNP (rs757343) in the VDR gene were analyzed using PCR-RFLP method. We observed no significant difference in genotype and allele frequencies between the women with PCOS and controls for the rs2059806, rs1799817, rs1501299, rs6256, and rs757343 polymorphisms either before or after adjustment for confounding factors including age and BMI. However, the ADIPOQ rs2241766 “TT” genotype compared with “TG and GG” genotypes was associated with a 1.93-fold increased risk for PCOS (P = 0.006, OR = 1.93, 95% CI = 1.20–3.11), and the differences remained significant after adjustment for age and BMI (P = 0.039, OR = 1.72, 95% CI = 1.03–2.86). Furthermore, the ADIPOQ rs2241766 “T” allele was significantly overrepresented in women with PCOS than controls (P = 0.006; OR = 1.80, 95% CI = 1.18–2.70), and the difference remained significant after Bonferroni correction. Our findings suggest that the ADIPOQ rs2241766 “TT” genotype is a marker of increased PCOS susceptibility. This study also indicates for the first time that there are no significant association between INSR rs2059806, PTH rs6256, and VDR rs757343 gene polymorphisms and PCOS risk. However, these data remain to be confirmed in larger studies and in other populations.


Adiponectin gene PCR-RFLP Polycystic ovary syndrome 



The authors thank all patients and healthy blood donors for providing blood samples. This work was supported by a grant from the Royan Institute.


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Fariba Ranjzad
    • 1
  • Touraj Mahmoudi
    • 2
  • Atena Irani Shemirani
    • 1
  • Aidin Mahban
    • 1
  • Abdolrahim Nikzamir
    • 3
  • Mohsen Vahedi
    • 4
  • Mahnaz Ashrafi
    • 5
  • Hamid Gourabi
    • 2
  1. 1.Research Center for Gastroenterology and Liver DiseasesShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of GeneticsReproductive Biomedicine Research Center, Royan InstituteTehranIran
  3. 3.Department of Biochemistry, Faculty of MedicineAhwaz Jondi Shapour University of Medical SciencesAhwazIran
  4. 4.Department of Epidemiology and Biostatistics, School of Public HealthTehran University of Medical SciencesTehranIran
  5. 5.Department of Endocrinology and Female InfertilityReproductive Biomedicine Research Center, Royan InstituteTehranIran

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