Molecular Biology Reports

, Volume 39, Issue 2, pp 1343–1347

Prevalence of the NKG2D Thr72Ala polymorphism in patients with systemic lupus erythematosus

  • Piotr Piotrowski
  • Margarita Lianeri
  • Marzena Olesińska
  • Paweł P. Jagodziński
Article

DOI: 10.1007/s11033-011-0868-1

Cite this article as:
Piotrowski, P., Lianeri, M., Olesińska, M. et al. Mol Biol Rep (2012) 39: 1343. doi:10.1007/s11033-011-0868-1

Abstract

Multiple studies have indicated that SLE incidence exhibits a strong genetic background. We studied the frequency of the natural killer group 2, member D (NKG2D) receptor Thr72Ala (rs2255336) polymorphism in patients with SLE (n = 243) and controls (n = 502) in a sample of the Polish population. The p value for SLE patients with the Thr/Thr genotype was 0.0455 and Odds Ratio (OR) = 0.3846 (95% CI = 0.1458–1.014). For the Thr/Thr and Ala/Thr genotypes we found p = 0.0135 and OR = 0.6556 (95% CI = 0.4684–0.9177). The frequency of the NKG2D 72Thr allele in patients and controls was respectively, 15 and 21%, P = 0.0046, OR = 0.6547 (95% CI = 0.4877–0.8789). Our studies may confirm that the NKG2D 72Thr gene variant may protect against the incidence of SLE.

Keywords

SLE NKG2D Polymorphisms 

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Piotr Piotrowski
    • 1
  • Margarita Lianeri
    • 1
  • Marzena Olesińska
    • 2
  • Paweł P. Jagodziński
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Medical SciencesPoznańPoland
  2. 2.Institute of RheumatologyWarsawPoland

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