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Molecular Biology Reports

, Volume 39, Issue 2, pp 1225–1229 | Cite as

Genetic variants of SDF-1 and CXCR4 genes in endometrial carcinoma

  • Canan Cacina
  • Sibel Bulgurcuoglu-Kuran
  • Ahmet Cem Iyibozkurt
  • Ilhan Yaylim-Eraltan
  • Bedia CakmakogluEmail author
Article

Abstract

In this study, we aimed to investigate a possible association between the Stromal cell-derived factor-1 (SDF-1) and CXCR4 polymorphisms and the risk of developing endometrial carcinoma. SDF-1 3′A and CXCR4 gene polymorphisms was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism in 139 healthy individuals and 113 patients with endometrial carcinoma. In our study groups SDF-1 3′A AA genotype frequency was higher in patients that of controls and individuals who had AA genotype showed a 2.6-fold increased risk for endometrial cancer. The carriers of CXCR4 T allele were higher in patients compared with controls and individuals who had TT genotype had a 2.5-fold high risk for endometrial carcinoma. Our finding suggest that there was no significant association between the (SDF-1) and CXCR4 polymorphisms and endometrium cancer risk. Further studies in a larger population are needed to better elucidate the role of (SDF-1) and CXCR4 gene polymorphisms in the risk of endometrial carcinogenesis. To the best of our knowledge, this is the first study to show such an association.

Keywords

SDF-1 CXCR4 Chemokin Endometrial carcinoma Polymorphism 

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Canan Cacina
    • 1
  • Sibel Bulgurcuoglu-Kuran
    • 1
  • Ahmet Cem Iyibozkurt
    • 2
  • Ilhan Yaylim-Eraltan
    • 1
  • Bedia Cakmakoglu
    • 1
    Email author
  1. 1.Department of Molecular Medicine, Institute of Experimental Medicine ResearchIstanbul UniversityIstanbulTurkey
  2. 2.Department of Obstetrics and Gynecology, Istanbul Medical SchoolIstanbul UniversityIstanbulTurkey

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