Molecular Biology Reports

, Volume 39, Issue 1, pp 607–612 | Cite as

CYP2E1 Rsa I/Pst I polymorphism contributes to oral cancer susceptibility: a meta-analysis

  • Yuming Niu
  • Yuanyuan Hu
  • Mingyue Wu
  • Fei Jiang
  • Ming Shen
  • Chunbo Tang
  • Ning Chen
Article

Abstract

Previous data on association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk were controversial. To investigate the association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk. We performed a meta-analysis to assess the relationship between oral cancer and genotype with English language until June 2010. Twelve published case–control studies of 1259 patients with oral cancer and 2262 controls were acquired. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association in codominant and dominant models. Overall, the pooled ORs indicated a significant association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk (for c1/c2 vs. c1/c1: OR = 1.30, 95% CI = 1.04–1.62, Pheterogeneity = 0.57; for (c1/c2 + c2/c2) vs. c1/c1: OR = 1.32, 95% CI = 1.07–1.64, Pheterogeneity = 0.57, respectively). In subgroup analysis by race, the same significant risks were found among Asian (for c1/c2 vs. c1/c1: OR = 1.41, 95% CI = 1.05–1.91, Pheterogeneity = 0.92; for (c1/c2 + c2/c2) vs. c1/c1: OR = 1.43, 95% CI = 1.08–1.88, Pheterogeneity = 0.97, respectively). In conclusion, this meta-analysis demonstrates that CYP2E1 Rsa I/Pst I c2 allele may be a biomarker for oral cancer, especially among Asian populations.

Keywords

CYP2E1 Polymorphism Oral cancer Meta-analysis 

Notes

Acknowledgment

We are grateful to Dr. Zhangwei Wang for statistics instruction and Dr. Zilu Wang, Dr. Mifang Yang for linguistic revision of this manuscript. This work was supported by grants from the Medical Development Foundation of Health Department of Jiangsu Province (H200811) and the Project of Natural Science of Colleges and Universities of Anhui Province (KJ2010A182).

Conflict of interest

None.

References

  1. 1.
    Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108PubMedCrossRefGoogle Scholar
  2. 2.
    Lai C, Shields PG (1999) The role of interindividual variation in human carcinogenesis. J Nutr 129:552S–555SPubMedGoogle Scholar
  3. 3.
    Tanaka E, Terada M, Misawa S (2000) Cytochrome P450 2E1: its clinical and toxicological role. J Clin Pharm Ther 25:165–175PubMedCrossRefGoogle Scholar
  4. 4.
    Tan W, Song N, Wang GQ, Liu Q, Tang HJ, Kadlubar FF et al (2000) Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China. Cancer Epidemiol Biomarkers Prev 9:551–556PubMedGoogle Scholar
  5. 5.
    Guo YM, Wang Q, Liu YZ, Chen HM, Qi Z, Guo QH (2008) Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males World. J Gastroenterol 14:1444–1449Google Scholar
  6. 6.
    Zhan P, Wang J, Zhang Y, Qiu LX, Zhao SF, Qian Q et al (2010) CYP2E1 Rsa I/Pst I polymorphism is associated with lung cancer risk among Asians. Lung Cancer 69:19–25PubMedCrossRefGoogle Scholar
  7. 7.
    Qin JM, Yang L, Chen B, Wang XM, Li F, Liao PH et al (2008) Interaction of methylenetetrahydrofolate reductase C677T, cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population World. J Gastroenterol 14:6986–6992Google Scholar
  8. 8.
    Boccia S, De Lauretis A, Gianfagna F, van Duijn CM, Ricciardi G (2007) CYP2E1PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: a meta-analysis of the literature. Carcinogenesis 28:101–106PubMedCrossRefGoogle Scholar
  9. 9.
    Hung HC, Chuang J, Chien YC, Chern HD, Chiang CP, Kuo YS et al (1997) Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer. Cancer Epidemiol Biomarkers Prev 6:901–905PubMedGoogle Scholar
  10. 10.
    Little J, Bradley L, Bray MS, Clyne M, Dorman J, Ellsworth DL et al (2002) Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations. Am J Epidemiol 156:300–310PubMedGoogle Scholar
  11. 11.
    Lau J, Ioannidis JP, Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127:820–826PubMedGoogle Scholar
  12. 12.
    DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188PubMedCrossRefGoogle Scholar
  13. 13.
    Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719–748PubMedGoogle Scholar
  14. 14.
    Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634PubMedCrossRefGoogle Scholar
  15. 15.
    Katoh T, Kaneko S, Kohshi K, Munaka M, Kitagawa K, Kunugita N et al (1999) Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer. Int J Cancer 83:606–609PubMedCrossRefGoogle Scholar
  16. 16.
    Morita S, Yano M, Tsujinaka T, Akiyama Y, Taniguchi M, Kaneko K et al (1999) Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to head-and-neck squamous-cell carcinoma. Int J Cancer 80:685–688PubMedCrossRefGoogle Scholar
  17. 17.
    Bouchardy C, Hirvonen A, Coutelle C, Ward PJ, Dayer P, Benhamou S (2000) Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. Int J Cancer 87:734–740PubMedCrossRefGoogle Scholar
  18. 18.
    Liu S, Park JY, Schantz SP, Stern JC, Lazarus P (2001) Elucidation of CYP2E1 5′ regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer. Oral Oncol 37:437–445PubMedCrossRefGoogle Scholar
  19. 19.
    Zavras AI, Wu T, Laskaris G, Wang YF, Cartsos V, Segas J et al (2002) Interaction between a single nucleotide polymorphism in the alcohol dehydrogenase 3 gene, alcohol consumption and oral cancer risk. Int J Cancer 97:526–530PubMedCrossRefGoogle Scholar
  20. 20.
    Gattas GJ, de Carvalho MB, Siraque MS, Curioni OA, Kohler P, Eluf-Neto J et al (2006) Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer. Head Neck 28:819–826PubMedCrossRefGoogle Scholar
  21. 21.
    Marques CF, Koifman S, Koifman RJ, Boffetta P, Brennan P, Hatagima A (2006) Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro. Oral Oncol 42:632–637PubMedCrossRefGoogle Scholar
  22. 22.
    Sugimura T, Kumimoto H, Tohnai I, Fukui T, Matsuo K, Tsurusako S et al (2006) Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. J Oral Pathol Med 35:11–18PubMedCrossRefGoogle Scholar
  23. 23.
    Buch SC, Nazar-Stewart V, Weissfeld JL, Romkes M (2008) Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes. Head Neck 30:1139–1147PubMedCrossRefGoogle Scholar
  24. 24.
    Soya SS, Vinod T, Reddy KS, Gopalakrishnan S, Adithan C (2008) CYP2E1 polymorphisms and gene-environment interactions in the risk of upper aerodigestive tract cancers among Indians. Pharmacogenomics 9:551–560PubMedCrossRefGoogle Scholar
  25. 25.
    Jia WH, Pan QH, Qin HD, Xu YF, Shen GP, Chen L et al (2009) A case-control and a family-based association study revealing an association between CYP2E1 polymorphisms and nasopharyngeal carcinoma risk in Cantonese. Carcinogenesis 30:2031–2036PubMedCrossRefGoogle Scholar
  26. 26.
    Zeng YX, Jia WH (2002) Familial nasopharyngeal carcinoma Semin. Cancer Biol 12:443–450CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Yuming Niu
    • 1
    • 2
  • Yuanyuan Hu
    • 2
  • Mingyue Wu
    • 1
    • 3
  • Fei Jiang
    • 1
  • Ming Shen
    • 1
  • Chunbo Tang
    • 1
  • Ning Chen
    • 1
  1. 1.Institute of Dental Research, School of StomatologyNanjing Medical UniversityNanjingPeople’s Republic of China
  2. 2.Department of StomatologyTaihe Hospital, Yunyang Medical CollegeShiyanPeople’s Republic of China
  3. 3.School of StomatologyAnhui Medical UniversityHefeiPeople’s Republic of China

Personalised recommendations