Molecular Biology Reports

, Volume 39, Issue 1, pp 607–612 | Cite as

CYP2E1 Rsa I/Pst I polymorphism contributes to oral cancer susceptibility: a meta-analysis

  • Yuming Niu
  • Yuanyuan Hu
  • Mingyue Wu
  • Fei Jiang
  • Ming Shen
  • Chunbo Tang
  • Ning Chen


Previous data on association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk were controversial. To investigate the association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk. We performed a meta-analysis to assess the relationship between oral cancer and genotype with English language until June 2010. Twelve published case–control studies of 1259 patients with oral cancer and 2262 controls were acquired. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association in codominant and dominant models. Overall, the pooled ORs indicated a significant association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk (for c1/c2 vs. c1/c1: OR = 1.30, 95% CI = 1.04–1.62, Pheterogeneity = 0.57; for (c1/c2 + c2/c2) vs. c1/c1: OR = 1.32, 95% CI = 1.07–1.64, Pheterogeneity = 0.57, respectively). In subgroup analysis by race, the same significant risks were found among Asian (for c1/c2 vs. c1/c1: OR = 1.41, 95% CI = 1.05–1.91, Pheterogeneity = 0.92; for (c1/c2 + c2/c2) vs. c1/c1: OR = 1.43, 95% CI = 1.08–1.88, Pheterogeneity = 0.97, respectively). In conclusion, this meta-analysis demonstrates that CYP2E1 Rsa I/Pst I c2 allele may be a biomarker for oral cancer, especially among Asian populations.


CYP2E1 Polymorphism Oral cancer Meta-analysis 



We are grateful to Dr. Zhangwei Wang for statistics instruction and Dr. Zilu Wang, Dr. Mifang Yang for linguistic revision of this manuscript. This work was supported by grants from the Medical Development Foundation of Health Department of Jiangsu Province (H200811) and the Project of Natural Science of Colleges and Universities of Anhui Province (KJ2010A182).

Conflict of interest



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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Yuming Niu
    • 1
    • 2
  • Yuanyuan Hu
    • 2
  • Mingyue Wu
    • 1
    • 3
  • Fei Jiang
    • 1
  • Ming Shen
    • 1
  • Chunbo Tang
    • 1
  • Ning Chen
    • 1
  1. 1.Institute of Dental Research, School of StomatologyNanjing Medical UniversityNanjingPeople’s Republic of China
  2. 2.Department of StomatologyTaihe Hospital, Yunyang Medical CollegeShiyanPeople’s Republic of China
  3. 3.School of StomatologyAnhui Medical UniversityHefeiPeople’s Republic of China

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