Molecular Biology Reports

, Volume 39, Issue 1, pp 221–226

A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy

  • Bo Jin
  • Xin-Ping Luo
  • Huan-Chun Ni
  • Wei Shen
  • Hai-Ming Shi
  • Yong Li
Article

Abstract

Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR polymorphism and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 19 case–control studies including 1,378 cases and 10,383 controls provided data on the association between HLA-DR polymorphism and genetic susceptibility to IDC. Overall, statistically elevated frequencies of HLA-DR4 (OR 1.58; 95% CI 1.21–2.07; P = 0.0009) and HLA-DR5 (OR 1.35; 95% CI 1.05–1.73; P = 0.02) alleles were found in patients with IDC compared with controls. Individuals with HLA-DR3 antigen have a protective effect against IDC (OR 0.72; 95% CI 0.58–0.90; P = 0.004). In summary, this meta-analysis indicated that certain HLA-DR alleles may be genetic markers for susceptibility and resistance to IDC.

Keywords

HLA-DR Dilated cardiomyopathy Polymorphism Meta-analysis 

Supplementary material

11033_2011_729_MOESM1_ESM.doc (32 kb)
Supplementary material 1 (DOC 32 kb)

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Bo Jin
    • 1
  • Xin-Ping Luo
    • 1
  • Huan-Chun Ni
    • 1
  • Wei Shen
    • 1
  • Hai-Ming Shi
    • 1
  • Yong Li
    • 1
  1. 1.Department of CardiologyHuashan Hospital, Fudan UniversityShanghaiChina

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