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Molecular Biology Reports

, Volume 38, Issue 7, pp 4537–4543 | Cite as

APE1 Asp148Glu gene polymorphism and lung cancer risk: a meta-analysis

  • Ya-Nan Ji
  • Ping ZhanEmail author
  • Jing Wang
  • Li-Xin Qiu
  • Li-Ke YuEmail author
Article

Abstract

Many studies have examined the association between the APE1 T1349G (Asp148Glu) gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. The PubMed, Embase, Web of Science, and CNKI database was searched for case–control studies published up to June 2010. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Ultimately, ten studies, comprising 2,696 lung cancer cases and 3,948 controls were included. Overall, for the G allele carriers (TG + GG) versus homozygote TT, the pooled OR was 1.037 (95% CI = 0.928–1.159 P = 0.001 for heterogeneity), for GG versus TT the pooled OR was 0.997 (95% CI = 0.861–1.154 P = 0.005 for heterogeneity). In the stratified analysis by ethnicity, significantly risks were not found among Asians or Caucasians. However, in the subgroup analyses by smoking status, significantly risks were found among smokers not in non-smokers. This meta-analysis suggested that the APE1 T1349G (Asp148Glu) polymorphism was not associated with lung cancer risk among Asians or Caucasians. But, the APE1 G allele was an increased risk factor for developing lung cancer among smokers.

Keywords

APE1 Polymorphism Lung cancer Susceptibility Meta-analysis 

Notes

Acknowledgments

This work was supported in part by a grant from the Major Program of Nanjing Medical Science and Technique Development Foundation In 2007 (Molecular Predictor of Personalized Therapy for Chinese Patients with Non-small Cell Lung Cancer) (Lk-Yu).

Conflicts of interest

The authors declare no any conflicts of interest in this work.

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Jiangsu Province Hospital of Traditional Chinese MedicineNanjingChina
  2. 2.First Department of Respiratory MedicineNanjing Chest HospitalNanjingChina
  3. 3.Department of HematologyThe Affiliated DrumTower Hospital of Nanjing University School of MedicineNanjingChina
  4. 4.Department of Medical Oncology, Cancer Hospital, Shanghai Medical CollegeFudan UniversityShanghaiChina

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