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Molecular Biology Reports

, Volume 38, Issue 6, pp 4225–4230 | Cite as

Sphingosine-1-phosphate: a potential therapeutic target for rheumatoid arthritis

  • Peng-fei Hu
  • Yi Chen
  • Peng-fei Cai
  • Li-feng Jiang
  • Li-dong Wu
Article

Abstract

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, which has as its primary target, the synovial tissues and articular cartilage. The current pharmacological treatment of RA includes non-steroidal anti-inflammatory drugs, corticosteroids, and disease-modifying anti-rheumatic drugs. Newer biological agents that work by inactivation of proinflammatory cytokines are available for treatment of RA. Sphingosine-1-phosphate (S1P) is a bioactive lipid that is generated from phosphorylation of sphingosine by activation of sphingosine kinase, and has been implicated as an important mediator in pathophysiological processes, including cell growth, differentiation, migration and survival, and angiogenesis. Several studies have explored the role of S1P in the pathogenesis of RA. The aim of this article was to review the biology and distribution of S1P, together with its role in RA, and to discuss its potential as a therapeutic target for RA.

Keywords

Rheumatoid arthritis Sphingosine-1-phosphate Sphingosine kinase Therapeutic target 

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Peng-fei Hu
    • 1
  • Yi Chen
    • 2
  • Peng-fei Cai
    • 1
  • Li-feng Jiang
    • 1
  • Li-dong Wu
    • 1
  1. 1.Department of Orthopedics Surgerythe Second Affiliated Hospital of Medical College, Zhejiang UniversityHangzhouPeople’s Republic of China
  2. 2.Department of Neurologythe Second Affiliated Hospital, College of Medicine, Zhejiang UniversityZhejiangPeople’s Republic of China

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