Molecular Biology Reports

, Volume 38, Issue 6, pp 4193–4196 | Cite as

Long-term intraperitoneal injection of lipopolysaccharide induces high expression of Id2 in the brain of mice

  • Le-Yu Wang
  • Zeng-zhi Niu
  • Bian-xiang Hu
  • Jia-ming Wu
  • Xuan Jiang
  • Xiao-fang Hu
  • Wen-hua Huang
  • Jun Ouyang
  • Lei Yu
  • Xiao-Zhong Qiu
Article
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Accepted:

Abstract

Lipopolysaccharide (LPS) from gram negative bacteria plays an important role in the pathophysiology of neurodegenerative diseases. Many evidences showed that LPS-induced neuroinflammation is related to upregulation of NF-kappaB. Here, we report that long-term treatment of lower dosage LPS mainly causes upregulation of Id2 protein. As an inhibitor of cell differentiation, Id2 plays an import role in adult olfactory neurogenesis. However, Id2 protein in brain acts as two edges in a sword, persist over-expression of Id2 in brain can induce neurodamages and may be related to neurodegeneration.

Keywords

Lipopolysaccharide Id2 NF-kappaB Brain 
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Notes

Acknowledgments

This work was supported by National Natural Science Foundation of China (30772196).

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Le-Yu Wang
    • 1
  • Zeng-zhi Niu
    • 1
  • Bian-xiang Hu
    • 1
  • Jia-ming Wu
    • 1
  • Xuan Jiang
    • 1
  • Xiao-fang Hu
    • 1
  • Wen-hua Huang
    • 1
  • Jun Ouyang
    • 1
  • Lei Yu
    • 1
  • Xiao-Zhong Qiu
    • 1
  1. 1.Department of AnatomySouthern Medical UniversityGuangzhouChina

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