Molecular Biology Reports

, Volume 38, Issue 6, pp 3821–3828 | Cite as

The effects of simvastatin on angiogenesis: studied by an original model of atherosclerosis and acute myocardial infarction in rabbit

  • Wei Shen
  • Hai-Ming Shi
  • Wei-Hu Fan
  • Xin-Ping Luo
  • Bo Jin
  • Yong Li
Article

Abstract

Statins have shown pleiotropic effects, many of them independent of their impact on lipids. Angiogenesis can be beneficial in the acute myocardial infarction to improve circulation. However, it also can be harmful due to worsening of atherosclerosis. Here, we established a new minimal invasive rabbit model to study ischemic myocardium and atherosclerosis together to mimic clinical scenario. We demonstrated that simvastatin has the effect of pro-angiogenesis and further improve cardiac function in ischemic myocardium, as well as the effect of anti-angiogenesis to improve atherosclerosis in aorta vessels.

Keywords

Statins Angiogenesis Myocardial infarction Atherosclerosis 

Notes

Acknowledgments

We are grateful of Dr. Shao-Hua Chen’s advice of study design and manuscript and Dr. Xiao-Long Zhang for his technical help. This study is supported by the funding of the Natural Science Foundation of China (no. 30873350) and the City Health Administration Project of Shanghai (no. 2009006).

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Wei Shen
    • 1
  • Hai-Ming Shi
    • 1
  • Wei-Hu Fan
    • 1
  • Xin-Ping Luo
    • 1
  • Bo Jin
    • 1
  • Yong Li
    • 1
  1. 1.Department of Cardiology, Huashan HospitalFudan UniversityShanghaiPeople’s Republic of China

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