Molecular Biology Reports

, Volume 38, Issue 4, pp 2409–2416 | Cite as

Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer

  • Dong Lu
  • Xiaodan Yu
  • Yukai Du


Many studies have investigated the association between the CYP2E1 5′-flanking region (RsaI/PstI) polymorphism and head and neck cancer susceptibility, but the results were conflicting. In this meta-analysis, we assessed 24 published studies involving 12,562 subjects of the association between CYP2E1 RsaI/PstI polymorphism and head and neck cancer risk. Using the fixed effects model, we found significant association between PstI/RsaI polymorphism and head and neck cancer risk [OR = 1.11 (95%CI: 1.00–1.22) for c2 allele (P = 0.04) and OR = 1.57 (95% CI: 1.14–2.15) for c2 homozygous (P = 0.006) compared with wild type homozygote]. Significant results were also found in East Asians and Mix populations when stratified by ethnicity. However, no significant associations were found for Caucasians in all genetic models. Stratified analyses according to source of controls, significant associations were found only in hospital base controls. In the subgroup analyses by tumor types, significant association was detected only in oral cancer group, while no significant associations among laryngeal- or pharyngeal- cancer subgroup. This meta-analysis suggests that the CYP2E1 RsaI/PstI polymorphism may be a risk factor for head and neck cancer in Asians and Mix population, and that different carcinogenic processes involved in the genesis of various tumor types may exist.


CYP2E1 Polymorphism Head and neck cancer Meta-analysis 



Confidence interval


Squamous cell carcinoma of head and neck


Hardy–Weinberg equilibrium


Odds ratio

Supplementary material

11033_2010_375_MOESM1_ESM.doc (58 kb)
Supplementary material 1 (DOC 57 kb)


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.The Chinese Medical HospitalQin ZhouPeople’s Republic of China
  2. 2.Xinhua HospitalShanghai Jiaotong University School of MedicineShanghaiPeople’s Republic of China
  3. 3.School of Public HealthTongJi Medical College of Huazhong University of Science and TechnologyWuhanPeople’s Republic of China

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