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Molecular Biology Reports

, Volume 38, Issue 4, pp 2409–2416 | Cite as

Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer

  • Dong Lu
  • Xiaodan Yu
  • Yukai Du
Article

Abstract

Many studies have investigated the association between the CYP2E1 5′-flanking region (RsaI/PstI) polymorphism and head and neck cancer susceptibility, but the results were conflicting. In this meta-analysis, we assessed 24 published studies involving 12,562 subjects of the association between CYP2E1 RsaI/PstI polymorphism and head and neck cancer risk. Using the fixed effects model, we found significant association between PstI/RsaI polymorphism and head and neck cancer risk [OR = 1.11 (95%CI: 1.00–1.22) for c2 allele (P = 0.04) and OR = 1.57 (95% CI: 1.14–2.15) for c2 homozygous (P = 0.006) compared with wild type homozygote]. Significant results were also found in East Asians and Mix populations when stratified by ethnicity. However, no significant associations were found for Caucasians in all genetic models. Stratified analyses according to source of controls, significant associations were found only in hospital base controls. In the subgroup analyses by tumor types, significant association was detected only in oral cancer group, while no significant associations among laryngeal- or pharyngeal- cancer subgroup. This meta-analysis suggests that the CYP2E1 RsaI/PstI polymorphism may be a risk factor for head and neck cancer in Asians and Mix population, and that different carcinogenic processes involved in the genesis of various tumor types may exist.

Keywords

CYP2E1 Polymorphism Head and neck cancer Meta-analysis 

Abbreviations

CI

Confidence interval

HNSCC

Squamous cell carcinoma of head and neck

HWE

Hardy–Weinberg equilibrium

OR

Odds ratio

Supplementary material

11033_2010_375_MOESM1_ESM.doc (58 kb)
Supplementary material 1 (DOC 57 kb)

References

  1. 1.
    Sankaranarayanan R, Masuyer E, Swaminathan R, Ferlay J, Whelan S (1998) Head and neck cancer: a global perspective on epidemiology and prognosis. Anticancer Res 18:4779–4786PubMedGoogle Scholar
  2. 2.
    Blot WJ, McLaughlin JK et al (1998) Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 48:3282–3287Google Scholar
  3. 3.
    Lewin F, Norell SE, Johansson H, Gustavsson P, Wennerberg J, Biörklund A, Rutqvist LE (1998) Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck: a population-based case–referent study in Sweden. Cancer 82:1367–1375PubMedCrossRefGoogle Scholar
  4. 4.
    Maier H, Dietz A, Gewelke U, Heller WD, Weidauer H (1992) Tobacco and alcohol and the risk of head and neck cancer. Clin Invest 70:320–327CrossRefGoogle Scholar
  5. 5.
    Muscat JE, Wynder EL (1992) Tobacco, alcohol, asbestos and occupational risk factors for laryngeal cancer. Cancer 69:2244–2251PubMedCrossRefGoogle Scholar
  6. 6.
    Yamazaki H, Inui Y, Yun C, Guengerich FP, Shimada T (1992) Cytochrome P4502E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes. Carcinogenesis 13:1789–1794PubMedCrossRefGoogle Scholar
  7. 7.
    Bellec G, Dreano Y, Lozach P, Menez JF, Berthou F (1996) Cytochrome P450 metabolic dealkylation of nine N-nitroso-dialkylamines by human liver microsomes. Carcinogenesis 17:2029–2034PubMedCrossRefGoogle Scholar
  8. 8.
    Hoffmann D, Hecht SS (1985) Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions. Cancer Res 45:935–944PubMedGoogle Scholar
  9. 9.
    Hecht SS, Hoffmann D (1988) Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis 9:875–884PubMedCrossRefGoogle Scholar
  10. 10.
    Hayashi SI, Watanabe J, Kawajiri K (1991) Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J Biochem 110:559–565PubMedGoogle Scholar
  11. 11.
    Cochran WG (1954) The combination of estimates from different experiments. Biometrics 10:101–129CrossRefGoogle Scholar
  12. 12.
    Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719–748PubMedGoogle Scholar
  13. 13.
    DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188PubMedCrossRefGoogle Scholar
  14. 14.
    Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. British Med J 315:629–634Google Scholar
  15. 15.
    Lucas D, Menez C, Floch F, Gourlaouen Y, Sparfel O, Joannet I et al (1996) Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aero digestive tract cancer in alcoholic Caucasians. Alcohol Clin Exp Res 20:1033–1037PubMedCrossRefGoogle Scholar
  16. 16.
    Hung HC, Chuang J, Chien YC, Chern HD, Chiang CP, Kuo YS et al (1997) Genetic polymorphisms of CYP2E1, GSTM1, and GSTM3; environmental factors and risk of oral cancer. Cancer Epidemiol Biomarkers Prev 6:901–905PubMedGoogle Scholar
  17. 17.
    Hildesheim A, Anderson LM, Chen CJ et al (1997) CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst 89:1207–1212PubMedCrossRefGoogle Scholar
  18. 18.
    Matthias C, Bockmühl U, Jahnke V, Jones PW, Hayes JD, Alldersea J, Gilford J, Bailey L, Bath J, Worrall SF, Hand P, Fryer AA, Strange RC (1998) Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. Pharmacogenetics 8(2):91–100PubMedCrossRefGoogle Scholar
  19. 19.
    González MV, Alvarez V, Pello MF, Menéndez MJ, Suárez C, Coto E (1998) Genetic polymorphism of N-acetyltransferase-2, glutathione S-transferase-M1, and cytochromes P450IIE1 and P450IID6 in the susceptibility to head and neck cancer. J Clin Pathol 51(4):294–298PubMedCrossRefGoogle Scholar
  20. 20.
    Katoh T, Kaneko S, Kohshi K, Munaka M, Kitagawa K, Kunugita N, Ikemura K, Kawamoto T (1999) Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer. Int J Cancer 83:606–609PubMedCrossRefGoogle Scholar
  21. 21.
    Morita S, Yano M, Tsujinaka T, Akiyama Y, Taniguchi M, Kaneko K, Miki H, Fujii T, Yoshino K, Kusuoka H, Monden M (1999) Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to head-and-neck squamous-cell carcinoma. Int J Cancer 80:685–688PubMedCrossRefGoogle Scholar
  22. 22.
    Bouchardy C, Hirvonen A, Coutelle C, Ward PJ, Dayer P, Benhamou S (2000) Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. Int J Cancer 87:734–740PubMedCrossRefGoogle Scholar
  23. 23.
    Kongruttanachok N, Sukdikul S, Setavarin S et al (2001) Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: a correlative study. BMC Cancer 1:4PubMedCrossRefGoogle Scholar
  24. 24.
    Liu S, Park JY, Schantz SP, Stern JC, Lazarus P (2001) Elucidation of CYP2E1 5′ regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer. Oral Oncol 37:437–445PubMedCrossRefGoogle Scholar
  25. 25.
    Neuhaus T, Ko Y-D, Lorenzen K, Fronhoffs S, Harth V, Bröde P, Vetter H, Bolt HM, Pesch B, Brüning T (2004) Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer. Toxicol Lett 151:273–282PubMedCrossRefGoogle Scholar
  26. 26.
    Gajecka M, Rydzanicz M, Jaskula-Sztul R, Kujawski M, Szyfter W, Szyfter K (2005) CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma. Mutat Res 574:112–123PubMedCrossRefGoogle Scholar
  27. 27.
    Yang XR, Diehl S, Pfeiffer R, Chen CJ, Hsu WL, Dosemeci M, Cheng YJ, Sun B, Goldstein AM, Hildesheim A (2005) Evaluation of risk factors for nasopharyngeal carcinoma in high-risk nasopharyngeal carcinoma families in Taiwan. Cancer Epidemiol Biomarkers Prev 14:900–905PubMedCrossRefGoogle Scholar
  28. 28.
    Marques CFS, Koifman S, Koifman RJ, Boffetta P, Brennan P, Hatagima A (2006) Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro. Oral Oncol 42(6):632–637PubMedCrossRefGoogle Scholar
  29. 29.
    Li G, Liu Z, Sturgis EM, Chamberlain RM, Spitz MR, Wei Q (2005) CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomarkers Prev 14:1034–1036PubMedCrossRefGoogle Scholar
  30. 30.
    Sugimura T, Kumimoto H, Tohnai I, Fukui T, Matsuo K, Tsurusako S et al (2006) Gene–environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. J Oral Pathol Med 35:11–18PubMedCrossRefGoogle Scholar
  31. 31.
    Gattá GJF, de Carvalho MB, Siraque MS et al (2006) Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer. Head Neck 28(9):819–826CrossRefGoogle Scholar
  32. 32.
    Boccia S, Cadoni G, Sayed-Tabatabaei FA, Volante M, Arzani D, De Lauretis A, Cattel C, Almadori G, van Duijn CM, Paludetti G, Ricciardi G (2008) CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer. J Cancer Res Clin Oncol 134:93–100PubMedCrossRefGoogle Scholar
  33. 33.
    Soya SS, Vinod T, Reddy KS, Gopalakrishnan S, Adithan C (2008) CYP2E1 polymorphisms and gene-environment interactions in the risk of upper aerodigestive tract cancers among Indians. Pharmacogenomics 9:551–560PubMedCrossRefGoogle Scholar
  34. 34.
    Shama C, Buch, Valle, Nazar-Stewart, Joel L, MarjorieRomkes, Weissfeld (2008) Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes. Head Neck 30:1139–1147CrossRefGoogle Scholar
  35. 35.
    Ruwali M, Khan AJ, Shah PP, Singh AP, Pant MC, Parmar D (2009) Cytochrome P450 2E1 and head and neck cancer: interaction with genetic and environmental risk factors. Environ Mol Mutagen 50:473–482PubMedCrossRefGoogle Scholar
  36. 36.
    Olivieri EH, da Silva SD, Mendonça FF, Urata YN, Vidal DO, Faria MD, Nishimoto IN, Rainho CA, Kowalski LP, Rogatto SR (2009) CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients. Oral Oncol 45(9):e73–e79PubMedCrossRefGoogle Scholar
  37. 37.
    Tai J, Yang M, Ni X, Yu D, Fang J, Tan W, Huang Z, Wu C, Chen X, Wang G, Zhou W, Chen X, Zhang W, Ma L, Lin D, Han D (2010) Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population. Cancer Genet Cytogenet 196(1):76–82PubMedCrossRefGoogle Scholar
  38. 38.
    Garcia SM, Curioni OA, de Carvalho MB, Gattás GJ (2010) Polymorphisms in alcohol metabolizing genes and the risk of head and neck cancer in a Brazilian population. Alcohol Alcohol 45(1):6–12PubMedGoogle Scholar
  39. 39.
    Hirschhorn JN, Lohmueller K, Byrne E (2002) A comprehensive review of genetic association studies. Genet Med 4:45–61PubMedCrossRefGoogle Scholar
  40. 40.
    Lucas D, Menez C, Girre C, Berthou F, Bodenez P, Joannet I et al (1995) Cytochrome P4502E1 genotype and chloroxazone metabolism in healthy and alcoholic Caucasian subjects. Pharmacogenetics 5:298–304PubMedCrossRefGoogle Scholar
  41. 41.
    Kim RB, Yamazaki H, Chiba K, O’Shea D, Mimura M, Guengerich FP et al (1996) In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians. J Pharmacol Exp Ther 279:4–11PubMedGoogle Scholar
  42. 42.
    Rodriguez C, Calle EE, Miracle-McMahill HL, Tatham LM, Wingo PA, Thun MJ et al (1997) Family history and risk of fatal prostate cancer. Epidemiology 8:653–659PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.The Chinese Medical HospitalQin ZhouPeople’s Republic of China
  2. 2.Xinhua HospitalShanghai Jiaotong University School of MedicineShanghaiPeople’s Republic of China
  3. 3.School of Public HealthTongJi Medical College of Huazhong University of Science and TechnologyWuhanPeople’s Republic of China

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