Molecular Biology Reports

, Volume 38, Issue 3, pp 1697–1702

Cytochrome P450 2C19 polymorphism is associated with poor clinical outcomes in coronary artery disease patients treated with clopidogrel

  • Bo Jin
  • Huan-Chun Ni
  • Wei Shen
  • Jian Li
  • Hai-Ming Shi
  • Yong Li
Article

DOI: 10.1007/s11033-010-0282-0

Cite this article as:
Jin, B., Ni, HC., Shen, W. et al. Mol Biol Rep (2011) 38: 1697. doi:10.1007/s11033-010-0282-0

Abstract

Patients with lesser degrees of platelet inhibition in response to clopidogrel appear to be at increased risk for recurrent ischemic events. Cytochrome P450 (CYP) polymorphisms have been proposed as possible mechanisms for nonresponsiveness to clopidogrel. Published data on the association between CYP2C19*2 polymorphism and atherothrombotic events are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of eight prospective cohort studies including 2,345 patients carrying CYP2C19*2 variant allele and 5,935 cases with the wild-type genotype were included in this meta-analysis. Overall, borderline statistically significantly elevated risk of adverse clinical events was associated with genotyping 681G>A polymorphism (for AA + GA vs. GG: OR, 1.46; 95% CI, 1.01 to 2.13; P = 0.05). The summary odds ratio showed a significant association between the CYP2C19*2 polymorphism and an increased risk of cardiac mortality in the follow-up period (OR, 2.07; 95% CI, 1.22 to 3.52; P = 0.007). When studies evaluating myocadial infarction, stent thrombosis, and ischemic stroke, the presence of the variant allele was associated with significantly increased risks of recurrent atherothrombotic events. In summary, this meta-analysis indicated that CYP2C19*2 carrier status is significantly associated with an increased risk of adverse cardiovascular events.

Keywords

CYP2C19 Meta-analysis Coronary artery diseases Clopidogrel 

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Bo Jin
    • 1
  • Huan-Chun Ni
    • 1
  • Wei Shen
    • 1
  • Jian Li
    • 1
  • Hai-Ming Shi
    • 1
  • Yong Li
    • 1
  1. 1.Department of Cardiology, Huashan HospitalFudan UniversityShanghaiChina

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