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Molecular Biology Reports

, Volume 37, Issue 1, pp 235–239 | Cite as

Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence

  • Piotr Piotrowski
  • Robert Gasik
  • Margarita Lianeri
  • Dorota Cieślak
  • Mariusz Wudarski
  • Paweł Hrycaj
  • Jan K. Łącki
  • Paweł P. JagodzińskiEmail author
Article
  • 143 Downloads

Abstract

Endogenous sex hormones have been observed to have a role in systemic lupus erythematosus (SLE) predisposition. Sex hormone-binding globulin (SHBG) regulates the bioavailability of sex hormones to target tissues. Therefore, we examined the distribution of the SHBG functional polymorphism Asp327Asn (rs6259) in SLE patients (n = 150) and controls (n = 150) in a Polish population. We found a contribution of the SHBG327Asn variant to the development of SLE. Women with the Asp/Asn and Asn/Asn genotypes displayed a 2.630-fold increased risk of SLE (95% CI = 1.561–4.433, P = 0.0003). SHBG has a much higher affinity for testosterone than estradiol, and the SHBG327Asn variant displays a reduction of estradiol clearance. Therefore we suggest that the opposing effects of estrogens and testosterone on the immune system and imbalance in the levels of these hormones in SLE patients can be enhanced by the SHBG327Asn protein variant.

Keywords

SLE Polymorphism SHBG 

Notes

Acknowledgments

Supported by grant No 502-01-01124182-07474 from Poznań University of Medical Sciences.

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Piotr Piotrowski
    • 1
  • Robert Gasik
    • 1
  • Margarita Lianeri
    • 1
  • Dorota Cieślak
    • 2
  • Mariusz Wudarski
    • 3
  • Paweł Hrycaj
    • 2
  • Jan K. Łącki
    • 3
  • Paweł P. Jagodziński
    • 1
    Email author
  1. 1.Department of Biochemistry and Molecular BiologyPoznań University of Medical SciencesPoznanPoland
  2. 2.Department of Rheumatology and Clinical ImmunologyPoznan University of Medical SciencesPoznanPoland
  3. 3.Institute of RheumatologyWarsawPoland

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