The genetic relationship among Iranian ethnic groups: an anthropological view based on HLA class II gene polymorphism
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Highly polymorphic human leukocyte antigen (HLA) genes are considered as useful markers by molecular anthropologists to determine genetic relationship among populations. This review summarizes the results of molecular analyses of HLA class II gene polymorphism in 816 DNA samples from 11 Iranian ethnic groups. The genetic relationship of Iranians to Asians and Europeans has also been reported here. The results of this study revealed a close genetic relationship among Iranian subpopulations which were well separated from other Asian and European populations, however, a genetic similarity was observed among Iranians, Macedonians, Greeks, and Italians.
KeywordsAnthropology Ethnic groups HLA polymorphism Iran
This work was supported by grants from Shiraz University of Medical Sciences, Iranian Molecular Medicine Network and by Shiraz Institute of Cancer Research. We are grateful to all volunteers who have contributed in this project.
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