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Molecular Biology Reports

, 36:1943 | Cite as

The genetic relationship among Iranian ethnic groups: an anthropological view based on HLA class II gene polymorphism

  • Shirin Farjadian
  • Massao Ota
  • Hidetoshi Inoko
  • Abbas Ghaderi
Article

Abstract

Highly polymorphic human leukocyte antigen (HLA) genes are considered as useful markers by molecular anthropologists to determine genetic relationship among populations. This review summarizes the results of molecular analyses of HLA class II gene polymorphism in 816 DNA samples from 11 Iranian ethnic groups. The genetic relationship of Iranians to Asians and Europeans has also been reported here. The results of this study revealed a close genetic relationship among Iranian subpopulations which were well separated from other Asian and European populations, however, a genetic similarity was observed among Iranians, Macedonians, Greeks, and Italians.

Keywords

Anthropology Ethnic groups HLA polymorphism Iran 

Notes

Acknowledgments

This work was supported by grants from Shiraz University of Medical Sciences, Iranian Molecular Medicine Network and by Shiraz Institute of Cancer Research. We are grateful to all volunteers who have contributed in this project.

References

  1. 1.
    Solberg OD, Mack SJ, Lancaster AK et al (2008) Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies. Hum Immunol 69:443–464. doi: 10.1016/j.humimm.2008.05.001 PubMedCrossRefGoogle Scholar
  2. 2.
    Farjadian S, Moqadam FA, Ghaderi A (2006) HLA class II gene polymorphism in Parsees and Zoroastrians of Iran. Int J Immunogenet 33:185–191. doi: 10.1111/j.1744-313X.2006.00594.x PubMedCrossRefGoogle Scholar
  3. 3.
    Farjadian S, Naruse T, Kawata H et al (2004) Molecular analysis of HLA allele frequencies and haplotypes in Baloch of Iran compared with related populations of Pakistan. Tissue Antigens 64:581–587. doi: 10.1111/j.1399-0039.2004.00302.x PubMedCrossRefGoogle Scholar
  4. 4.
    Farjadian S, Ghaderi A (2007) HLA class II genetic diversity in Arabs and Jews of Iran. Iran J Immunol 4:85–93PubMedGoogle Scholar
  5. 5.
    Farjadian S, Ghaderi A (2007) HLA class II similarities in Iranian Kurds and Azeris. Int J Immunogenet 34:457–463. doi: 10.1111/j.1744-313X.2007.00723.x PubMedCrossRefGoogle Scholar
  6. 6.
    Frjadian S, Ghaderi A (2006) Iranian Lurs genetic diversity: an anthropological view based on HLA class II profiles. Iran J Immunol 3:106–113Google Scholar
  7. 7.
    Inoko H, Ota M (1993) PCR/RFLP. In: Hui KM, Bidwell JL (eds) Handbook of HLA typing techniques. CRC, Boca Raton, pp 9–70Google Scholar
  8. 8.
    Amirzargar A, Mytilineos J, Farjadian S et al (2001) Human leukocyte antigen class II allele frequencies and haplotype association in Iranian normal population. Hum Immunol 62:1234–1238. doi: 10.1016/S0198-8859(01)00320-2 PubMedCrossRefGoogle Scholar
  9. 9.
    Saruhan-Direskeneli G, Uyar FA, Bakar S et al (2000) Molecular analysis of HLA-DRB1, DQA1 and DQB1 polymorphism in Turkey. Tissue Antigens 55:171–174. doi: 10.1034/j.1399-0039.2000.550211.x PubMedCrossRefGoogle Scholar
  10. 10.
    Rajalingam R, Krausa P, Shilling HG et al (2002) Distinctive KIR and HLA diversity in a panel of north Indian Hindus. Immunogenetics 53:1009–1019. doi: 10.1007/s00251-001-0425-5 PubMedCrossRefGoogle Scholar
  11. 11.
    Vidan-Jeras B, Jurca B, Dolzan V et al (2007) Slovenian from Slovenia. In: Hansen JA (ed) Immunobiology of the Human MHC: Proceedings of the 13th International Histocompatibility Workshop and Conference, vol 1. IHWG, Seattle, pp 602–604Google Scholar
  12. 12.
    Sanchez-Velasco P, Gomez-Casado E, Martinez-Laso J et al (2003) HLA alleles in isolated populations from north Spain: origin of the Basques and the ancient Iberians. Tissue Antigens 61:384–392. doi: 10.1034/j.1399-0039.2003.00041.x PubMedCrossRefGoogle Scholar
  13. 13.
    Papassavas EC, Spyropoulou-Vlachou M, Papassavas AC et al (2000) MHC class I and class II phenotype, gene, and haplotype frequencies in Greeks using molecular typing data. Hum Immunol 61:615–623. doi: 10.1016/S0198-8859(00)00115-4 PubMedCrossRefGoogle Scholar
  14. 14.
    Petrone A, Bugawan TL, Mesturino CA et al (2001) The distribution of HLA class II susceptible/protective haplotypes could partially explain the low incidence of type 1 diabetes in continental Italy (Lazio region). Tissue Antigens 58:385–394. doi: 10.1034/j.1399-0039.2001.580607.x PubMedCrossRefGoogle Scholar
  15. 15.
    Constantinidou N, Chaidaroglou A, Van den Berg-Loonen EM et al (1998) Polymorphism and distribution of HLA-DR2 alleles and haplotypes in a Greek population. Tissue Antigens 52:153–157PubMedCrossRefGoogle Scholar
  16. 16.
    Bettinotti MP, McNicholas A, Keller E et al (1994) DRB11605: a new DR2-DRB1 allele found in a German family. Immunogenetics 39:300. doi: 10.1007/BF00188799 PubMedCrossRefGoogle Scholar
  17. 17.
    Meyer D, Singe RM, Mack SJ et al (2007) Single Locus Polymorphism of Classical HLA Genes. In: Hansen JA (ed) Immunobiology of the Human MHC: Proceedings of the 13th International Histocompatibility Workshop and Conference. vol I, IHWG, Seattle,pp 653–704Google Scholar
  18. 18.
    Quintana-Murci L, Krausz C, Zerjal T et al (2001) Y chromosome lineages trace diffusion of people and languages in southwestern Asia. Am J Hum Genet 68:537–542. doi: 10.1086/318200 PubMedCrossRefGoogle Scholar
  19. 19.
    Uinuk-Ool TS, Takezaki N, Sukernik RI et al (2002) Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies. Hum Genet 110:209–226. doi: 10.1007/s00439-001-0668-0 PubMedCrossRefGoogle Scholar
  20. 20.
    Almawi WY, Busson M, Tamim H et al (2004) HLA class II profile and distribution of HLA-DRB1 and HLA-DQB1 alleles and haplotypes among Lebanese and Bahraini Arabs. Clin Diagn Lab Immunol 11:770–774. doi: 10.1128/CDLI.11.4.770-774.2004 PubMedGoogle Scholar
  21. 21.
    Amar A, Kwon OJ, Motro U et al (1999) Molecular analysis of HLA class II polymorphisms among different ethnic groups in Israel. Hum Immunol 60:723–730. doi: 10.1016/S0198-8859(99)00043-9 PubMedCrossRefGoogle Scholar
  22. 22.
    Saito S, Ota S, Yamada E et al (2000) Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population. Tissue Antigens 56:522–529. doi: 10.1034/j.1399-0039.2000.560606.x PubMedCrossRefGoogle Scholar
  23. 23.
    Lin JH, Liu ZH, Lv FJ et al (2003) Molecular analyses of HLA-DRB1, DPB1, and DQB1 in Jing ethnic minority of southwest China. Hum Immunol 64:830–834. doi: 10.1016/S0198-8859(03)00128-9 PubMedCrossRefGoogle Scholar
  24. 24.
    Sanchez-Velasco P, Karadsheh NS, Garcia-Martin A et al (2001) Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations. Hum Immunol 62:901–909. doi: 10.1016/S0198-8859(01)00289-0 PubMedCrossRefGoogle Scholar
  25. 25.
    Lee KW, Oh DH, Lee C et al (2005) Allelic and haplotypic diversity of HLA-A, B, C, DRB1, and DQB1 genes in the Korean population. Tissue Antigens 65:437–447. doi: 10.1111/j.1399-0039.2005.00386.x PubMedCrossRefGoogle Scholar
  26. 26.
    Machulla HK, Batnasan D, Steinborn F et al (2003) Genetic affinities among Mongol ethnic groups and their relationship to Turks. Tissue Antigens 61:292–299. doi: 10.1034/j.1399-0039.2003.00043.x PubMedCrossRefGoogle Scholar
  27. 27.
    Al-Hussein KA, Rama NR, Butt AI et al (2002) HLA class II sequence-based typing in normal Saudi individuals. Tissue Antigens 60:259–261. doi: 10.1034/j.1399-0039.2002.600308.x PubMedCrossRefGoogle Scholar
  28. 28.
    Zhou L, Lin B, Xie Y et al (2005) Polymorphism of human leukocyte antigen DRB1, DQB1, and DPB1 genes of Shandong Han population in China. Tissue Antigens 66:37–43. doi: 10.1111/j.1399-0039.2005.00418.x PubMedCrossRefGoogle Scholar
  29. 29.
    Sanchez-Velasco P, Leyva-Cobian F (2001) The HLA class I and class II allele frequencies studied at the DNA level in the Svanetian population (Upper Caucasus) and their relationships to western European populations. Tissue Antigens 58:223–233. doi: 10.1034/j.1399-0039.2001.580402.x PubMedCrossRefGoogle Scholar
  30. 30.
    Martinez-Laso J, Sartakova M, Allende L et al (2001) HLA molecular markers in Tuvinians: a population with both Oriental and Caucasoid characteristics. Ann Hum Genet 65:245–261. doi: 10.1046/j.1469-1809.2001.6530245.x PubMedCrossRefGoogle Scholar
  31. 31.
    Arnaiz-Villena A, Dimitroski K, Pacho A et al (2001) HLA genes in Macedonians and the sub-Saharan origin of the Greeks. Tissue Antigens 57:118–127. doi: 10.1034/j.1399-0039.2001.057002118.x PubMedCrossRefGoogle Scholar
  32. 32.
    Cavalli-Sforza LL, Piazza A, Menozzi P et al (1998) Reconstruction of human evolution: bringing together genetic, archaeological, and linguistic data. Proc Natl Acad Sci USA 85:6002–6006. doi: 10.1073/pnas.85.16.6002 CrossRefGoogle Scholar
  33. 33.
    Arnaiz-Villena A, Iliakis P, Gonzalez-Hevilla M et al (1999) The origin of Cretan populations as determined by characterization of HLA alleles. Tissue Antigens 53:213–226. doi: 10.1034/j.1399-0039.1999.530301.x PubMedCrossRefGoogle Scholar
  34. 34.
    Ivaskova E, Bendukidze N (2007) Czech from Prague, Czech Republic. In: Hansen JA (ed) Immunobiology of the human MHC: Proceedings of the 13th International Histocompatibility Workshop and Conference.vol 1. IHWG, Seattle, pp 597–598Google Scholar
  35. 35.
    Muro M, Marin L, Torio A et al (2001) HLA polymorphism in the Murcia population (Spain): in the cradle of the archaeologic Iberians. Hum Immunol 62:910–921. doi: 10.1016/S0198-8859(01)00290-7 PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Shirin Farjadian
    • 1
    • 2
  • Massao Ota
    • 3
  • Hidetoshi Inoko
    • 4
  • Abbas Ghaderi
    • 1
    • 5
  1. 1.Immunology departmentShiraz University of Medical SciencesShirazIran
  2. 2.Allergy Research CenterShiraz University of Medical SciencesShirazIran
  3. 3.Department of Legal MedicineShinshu University School of MedicineMatsumoto, NaganoJapan
  4. 4.Department of Basic Medicine and Molecular MedicineToki University School of MedicineIsehara, KanagawaJapan
  5. 5.Institute of Cancer ResearchShiraz University of Medical SciencesShirazIran

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