Molecular Biology Reports

, Volume 35, Issue 1, pp 59–63

Expression of lipoprotein lipase associated with lung adenocarcinoma tissues

  • Jizhong Lu
  • Jixi Li
  • Chaoneng Ji
  • Weiyong Yu
  • Zhiyun Xu
  • Shengdong Huang
Short Communication

DOI: 10.1007/s11033-006-9053-3

Cite this article as:
Lu, J., Li, J., Ji, C. et al. Mol Biol Rep (2008) 35: 59. doi:10.1007/s11033-006-9053-3

Abstract

Lipoprotein lipase (LPL) plays a key role in the lipid metabolism and transporting. It can catalyze the hydrolysis of chylomicron and very low-density lipoprotein triglyceride. Moreover, the abnormality of LPL associates with many pathophysiological conditions. Herein cDNA microarray and Northern blots analysis were used to study the expression of lipoprotein lipase in lung adenocarcinoma tissues. There were 113 genes of all tested blots in cDNA microarray expressed lowly. LPL gene is expressed lowly at the average ratio 0.26 (Cy5/Cy3) in lung adenocarcinoma tissues over controls. Northern blots confirmed those changes detected from the cDNA microarray and suggested that low expression of LPL may play an important role in the lung adenocarcinoma development.

Keywords

Lipoprotein lipase Lung adenocarcinoma cDNA microarray Northern blots 

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Jizhong Lu
    • 1
  • Jixi Li
    • 2
  • Chaoneng Ji
    • 2
  • Weiyong Yu
    • 1
  • Zhiyun Xu
    • 1
  • Shengdong Huang
    • 1
  1. 1.Department of Cardiac-thoracic surgery, Changhai HospitalSecond Military Medical UniversityShanghaiChina
  2. 2.State Key Laboratory of Genetic Engineering, School of Life SciencesFudan UniversityShanghaiChina

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