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Ciprofloxacin-functionalized magnetic silica nanoparticles: as a reusable catalyst for the synthesis of 1H-chromeno[2,3-d]pyrimidine-5-carboxamides and imidazo[1,2-a]pyridines

  • Ebrahim SoleimaniEmail author
  • Sara Torkaman
  • Heshmatollah Sepahvand
  • Somayeh Ghorbani
Original Article

Abstract

In this research, synthesis and characterization of new surface-functionalized magnetic silica nanoparticles are reported. The magnetic silica nanoparticle was synthesized by a silica coating of the magnetite nanoparticles through a sol–gel process, and then, their surface was modified by (3-chloropropyl)triethoxysilane and covalently functionalized by ciprofloxacin. The catalyst activity of prepared functionalized nanoparticle was investigated by isocyanide-based multicomponent reactions for the synthesis of 1H-chromeno[2,3-d]pyrimidine-5-carboxamides and imidazo[1,2-a]pyridines. This catalyst was recycled by magnetic filtration and reprocessed five times without having a significant loss of catalytic activity.

Graphical abstract

Keywords

Magnetite nanocatalyst Ciprofloxacin Isocyanide-based multicomponent reactions 1H-Chromeno[2,3-d]pyrimidine-5-carboxamides Imidazo[1,2-a]pyridines 

Notes

Acknowledgements

We gratefully acknowledge financial support from the Iran National Science Foundation (INSF) and the Research Council of Razi University.

Supplementary material

11030_2018_9907_MOESM1_ESM.docx (5.4 mb)
Supplementary material 1 (DOCX 5515 kb)

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ebrahim Soleimani
    • 1
    Email author
  • Sara Torkaman
    • 1
  • Heshmatollah Sepahvand
    • 1
  • Somayeh Ghorbani
    • 1
  1. 1.Department of ChemistryRazi UniversityKermanshahIran

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