Synthesis of (E)-2-amino-N′-benzylidenehexahydroquinoline-3-carbohydrazide

  • Milad Masoumi
  • Fahimeh Sadat Hosseini
  • Mohammad BayatEmail author
Original Article


A one-pot, multi-component protocol for the synthesis of a new class of functionalized quinoline carbohydrazide derivatives via reaction of various anilines, dimedone, aromatic aldehydes, and cyanoacetohydrazide is described. The reactions are completed in the presence of catalytic amount of piperidine, respectively, in melt conditions and then in ethanol/water (1:1) as green solvent at 80 °C. Mild conditions, green medium, short reaction times, simple workup and purification process with no chromatographic technique, and good yields are the main advantages of this method.

Graphical abstract


Multi-component protocol Quinoline carbohydrazide derivatives Anilines Dimedone Aromatic aldehydes Cyanoacetohydrazide 

Supplementary material

11030_2018_9892_MOESM1_ESM.doc (16.8 mb)
Supplementary material 1 (DOC 17212 kb)


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceImam Khomeini International UniversityQazvinIran

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