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Effective synthesis of some novel pyrazolidine-3,5-dione derivatives via Mg(II) catalyzed in water medium and their anticancer and antimicrobial activities

  • Meera Moydeen
  • Radhakrishnan Surendra Kumar
  • Akbar Idhayadhulla
  • Aseer Manilal
Original Article
  • 41 Downloads

Abstract

Novel pyrazolidine-3,5-dione derivatives (2a–g, 4a–g, and 6a–g) were synthesized by an easy-to-perform Mg(II) acetylacetonate-catalyzed reaction with high yields using water as the reaction medium. Synthesized compounds were screened for anticancer and antimicrobial activities. The compound 6c (LD50 19.1 µg/mL) showed anticancer activity higher than that of all other compounds against MCF-7 breast cancer cell line. Results of antimicrobial activities revealed that the compound 4d (MIC 0.5 μg/mL) had higher activity than ciprofloxacin against Staphylococcus aureus, whereas the compound 2b (MIC 0.5 μg/mL) had higher activity than clotrimazole against Candida albicans. Overall results of this study envisaged that the compounds 2b, 4d, and 6c have the potential to be developed as anticancer and antimicrobial agents.

Graphical abstract

Novel pyrazolidine-3,5-dione derivatives (2a–g, 4a–g, and 6a–g) were synthesized via an easy-to perform Mg(II) catalysis in water medium. The synthesized compounds were screened for anticancer and antimicrobial activities.

Keywords

Pyrazolidine-3,5-dione derivative Mg(II) catalysis Antibacterial activity Antifungal activity Anticancer activity 

Notes

Acknowledgements

The project was supported by King Saud University, Deanship of Scientific Research, College of Science Research Center.

Supplementary material

11030_2018_9850_MOESM1_ESM.docx (4.3 mb)
Supplementary material 1 (DOCX 4365 kb)

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Petrochemical Research Chair, Department of Chemistry, College of ScienceKing Saud UniversityRiyadhSaudi Arabia
  2. 2.PG & Research Department of ChemistryNehru Memorial CollegePuthanampatti, Tiruchirappalli (Dt)India
  3. 3.Department of Medical Laboratory Science, College of Medicine and Health SciencesArba Minch UniversityArba MinchEthiopia

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