Molecular Diversity

, Volume 21, Issue 4, pp 865–873 | Cite as

Effective DABCO-catalyzed synthesis of new tetrazolo[1,5-a]pyrimidine analogs

  • Ramin Ghorbani-VagheiEmail author
  • Azadeh Shahriari
  • Jafar Mahmoodi
  • Yaser Maghbooli
Original Article


In this study, an efficient multicomponent one-pot route is described for the DABCO-catalyzed synthesis of tetrazolo[1,5-a]pyrimidines. This synthesis strategy is based on the reaction of malononitrile and aldehydes with 5-aminotetrazole monohydrate using 1,4-diazabicyclo[2.2.2]octane (DABCO) in i-PrOH under reflux conditions. This protocol is a simple, green, and low-cost technique to prepare new compounds with potential medicinal properties.

Graphical Abstract


DABCO Tetrazolo[1, 5-a]pyrimidines Multicomponent MCRs One-pot 5-aminotetrazole monohydrate 



We would like to thank Bu-Ali Sina University, Center of Excellence in Developmental of Environmentally Friendly Methods for Chemical Synthesis (CEDEFMCS) for financial support of this study.

Supplementary material

11030_2017_9760_MOESM1_ESM.docx (4.1 mb)
Supplementary material 1 (docx 4201 KB)
11030_2017_9760_MOESM2_ESM.docx (4.3 mb)
Supplementary material 2 (docx 4428 KB)


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Ramin Ghorbani-Vaghei
    • 1
    Email author
  • Azadeh Shahriari
    • 1
  • Jafar Mahmoodi
    • 1
  • Yaser Maghbooli
    • 1
  1. 1.Department of Organic Chemistry, Faculty of ChemistryBu-Ali Sina UniversityHamedanIran

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