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Molecular Diversity

, Volume 17, Issue 3, pp 515–524 | Cite as

Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer’s disease

  • Ying Ying Cao
  • Ling Wang
  • Hu Ge
  • Xi Lin Lu
  • Zhong Pei
  • Qiong GuEmail author
  • Jun Xu
Full-Length Paper

Abstract

The effects of Salvianolic acid A (Sal A) on the treatment of Alzheimer’s disease (AD) were investigated. Sal A significantly inhibits amyloid beta \((\text{ A }\beta )\) self-aggregation and disaggregates pre-formed \(\text{ A }\beta \) fibrils, reduces metal-induced \(\text{ A }\beta \) aggregation through chelating metal ions, and blocks the formation of reactive oxygen species (ROS) in SH-SY5Y cells. Sal A protects cells against \(\text{ A }\beta _{42}\)-induced toxicity. Furthermore, Sal A, possibly because of the effects of decreasing toxicity effects of \(\text{ A }\beta \) species, alleviates \(\text{ A }\beta \)-induced paralysis in transgenic Caenorhabditis elegans. Circular dichroism (CD) experiments and Molecular dynamic (MD) simulations demonstrate that Sal A inhibits \(\text{ A }\beta \) self-aggregation through binding to the C-terminus of \(\text{ A }\beta \), and therefore stabilizing the \(\alpha \)-helical conformations. Altogether, our data show that Sal A, as the multifunctional agent, is likely to be promising therapeutics for AD.

Keywords

Alzheimer’s disease Salvianolic acid A Amyloid \(\beta \) Anti-oxidant Neuroprotecitve 

Notes

Acknowledgments

This work was funded in part of the National Natural Science Foundation of China (No. 81001372, 81173470), the National High-tech R&D Program of China (863 Program) (2012AA020307), the introduction of innovative R&D team program of Guangdong Province (No. 2009010058), and the External Cooperation Program of Chinese Academy of Sciences (No. P2010-KF08). Some strains were provided by the CGC, which was funded by NIG Office of Research Infrastructure Programs (P40 OD010440). The authors thank Dr. Chaolun Liang for the assistance with TEM assay.

Conflict of interest    The authors declare no competing financial interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Ying Ying Cao
    • 1
  • Ling Wang
    • 1
  • Hu Ge
    • 1
  • Xi Lin Lu
    • 2
  • Zhong Pei
    • 2
  • Qiong Gu
    • 1
    Email author
  • Jun Xu
    • 1
  1. 1.Research Center for Drug Discovery, School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhouChina
  2. 2.Neurology Department of the First Affiliated Hospital Sun Yat-Sen UniversityGuangzhouChina

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