Molecular Diversity

, Volume 16, Issue 2, pp 335–350 | Cite as

Accessing a small library of pluripotent 1,4,5-trisubstituted 1H-1,2,3-triazoles via diversity-oriented synthesis

  • Arya Ajay
  • Munna Prasad Gupt
  • N. Devender
  • Rama P. Tripathi
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Abstract

Diversity-oriented synthesis of structurally different, novel and small drug like molecules based on 1,4,5-trisubstituted 1,2,3-triazoles is developed in a streamlined sequence of different sets of reactions. The method involves the use of simple, readily available and highly economical substrates and reagents. The molecules developed herein have potential to be exploited either as chemotherapeutic agents or as scaffolds for other biologically active compounds.

Keywords

β-Amino alocohols Benzoxazoles Dipolar cycloaddition Diversity-oriented synthesis 1,4,5-Trisubstituted-1H-1,2,3-triazoles 

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Arya Ajay
    • 1
  • Munna Prasad Gupt
    • 1
  • N. Devender
    • 1
  • Rama P. Tripathi
    • 1
  1. 1.Medicinal & Process Chemistry DivisionCSIR-Central Drug Research Institute (Council of Scientific and Industrial Research)LucknowIndia

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