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Molecular Diversity

, Volume 14, Issue 3, pp 479–491 | Cite as

One-pot multicomponent synthesis of two novel thiolactone scaffolds

  • B. Beck
  • S. Srivastava
  • K. Khoury
  • E. Herdtweck
  • Alexander Dömling
Full-length paper

Abstract

We designed two novel thiolactone scaffolds. Both scaffolds can be accessed by a convergent Ugi multicomponent reaction (MCR) and are, thus, amenable to library synthesis. Design, stereoselectivity, structures, full experimental details, and virtual libraries will be reported.

Keywords

Multicomponent reaction (MCR) Isocyanide Thiolactone Virtual library 

Abbreviations

MCR

Multicomponent reaction

HTMP

Homocysteine thiolactone-induced protein modification

HTL

Homocysteine thiolactone

UDC

Ugi–deprotection–cyclization sequences

IMCR

Isocyanide based MCR

FDA

Food and drug administration

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • B. Beck
    • 1
  • S. Srivastava
    • 1
  • K. Khoury
    • 1
  • E. Herdtweck
    • 2
  • Alexander Dömling
    • 1
  1. 1.Department of PharmacyUniversity of PittsburghPittsburghUSA
  2. 2.Technical University MunichMunichGermany

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