Molecular Diversity

, Volume 13, Issue 4, pp 399–419

One hundred years of Meldrum’s acid: advances in the synthesis of pyridine and pyrimidine derivatives



A general review (138 references) focused on the recent advances in the application of Meldrum’s acid reactivity for synthesis of diverse pyridine and pyrimidine derivatives, mostly small and drug-like molecules is presented.


Meldrum’s acid Pyridine Pyrimidine Azoloazines Tandem reactions Multicomponent cyclocondensations 


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.State Institution “V.Ya. Danilevsky Institute of Endocrine Pathology Problems”Academy of Medical Sciences of UkraineKharkovUkraine
  2. 2.Department of Chemistry of Heterocyclic CompoundsState Scientific Institution “Institute for Single Crystals”, National Academy of Sciences of UkraineKharkovUkraine
  3. 3.AG Limbach, Institute for Organic ChemistryFree University of BerlinBerlinGermany

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