Molecular Diversity

, Volume 12, Issue 2, pp 85–91

Diammonium hydrogen phosphate as a versatile and efficient catalyst for the one-pot synthesis of pyrano[2,3-d]pyrimidinone derivatives in aqueous media

  • Saeed Balalaie
  • Shahrzad Abdolmohammadi
  • Hamid Reza Bijanzadeh
  • Ali Mohammad Amani
Full Length Paper

Abstract

Diammonium hydrogen phosphate, (NH4)2HPO4, was used as a catalyst for one-pot, three-component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric/thiobarbituric acid in aqueous ethanol at room temperature. This method has the advantages of a simple operation, mild reaction conditions, high yields, by using a less toxic and low cost chemical as a catalyst.

Keywords

Aqueous media Diammonium hydrogen phosphate (DAHP) Pyrano[2, 3-d]pyrimidinone Domino Knoevenagel–Michael addition Multicomponent reaction (MCR) 

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Saeed Balalaie
    • 1
  • Shahrzad Abdolmohammadi
    • 2
  • Hamid Reza Bijanzadeh
    • 3
  • Ali Mohammad Amani
    • 1
  1. 1.Peptide Chemistry Research GroupK.N. Toosi University of TechnologyTehranIran
  2. 2.School of Chemistry College of ScienceUniversity of TehranTehranIran
  3. 3.Department of ChemistryTarbiat Modarres UniversityTehranIran

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