Molecular Diversity

, Volume 11, Issue 2, pp 107–111 | Cite as

Synthesis of C-11 modified mifepristone analog libraries

  • Gregory L. Hamilton
  • Bradley J. Backes
Short Communication


Substitution of the C-11 aniline of mifepristone can provide compounds with altered pharmacokinetic and pharmacodynamic (PK/PD) profiles that may find use for new indications. The development of new steroid intermediates and specialized library synthesis methods were required to enable the efficient preparation of structurally complex C-11 modified mifepristone analogs.


Library synthesis Mifepristone Parallel synthesis Steroids 


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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  1. 1.Metabolic Disease Research, Global Pharmaceutical Research and DevelopmentAbbott LaboratoriesAbbott ParkUSA

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