Use of nanoparticles for studying hemoglobin
- 76 Downloads
We present the advantages and features of comprehensive application of atomic force microscopy, laser interference microscopy, and Raman microscopy to study erythrocytes. We have determined the effectiveness of signal enhancement as a function of the size of silver nanoparticles in the Raman method. We consider the feasibility of using the developed techniques for clinical diagnosis.
Keywordserythrocyte hemoglobin Raman scattering silver colloids
This work was done with the financial support from the Ministry of Education and Science of the Russian Federation (State Contract No. 16.552.11.7049).
- 1.G. V. Maksimov et al., “Study of demyelination of nerve fiber using dynamic phase microscopy,” Byull. Eksperim. Biol. Meditsiny, 131, No. 5, 539–542 (2001).Google Scholar
- 3.L. A. Erokhova et al., “Application of laser interference microscopy to study regular intracellular and membrane processes in neurons,” Byull. Eksperim. Biol. Meditsiny, 140, No. 8, 237 (2005).Google Scholar
- 6.G. G. Levin, F. V. Bulygin, and G. N. Vishnyakov, “Coherent oscillations in the state of protein molecules in living cells,” Tsitologiya, 47, No. 4, 348–356 (2005).Google Scholar