Effect of coenzyme Q10 supplementation on diabetes induced memory deficits in rats

  • Ghazaleh Omidi
  • Seyed Asaad Karimi
  • Arezoo Rezvani-Kamran
  • Amirreza Monsef
  • Siamak Shahidi
  • Alireza KomakiEmail author
Original Article


The main objective of current work was to determine the effects of low and high dose supplementation with coenzyme Q10 (CoQ10) on spatial learning and memory in rats with streptozotocin (STZ)-induced diabetes. Male Wistar rats (weighing 220 ± 10) were randomly divided into six groups: (i) Control (Con, n = 8); (ii) Control+ Low dose of CoQ10 (100 mg/kg) (CLD, n = 10); (iii) Control+ high dose of CoQ10 (600 mg/kg) (CHD, n = 10); (iv) Diabetic (D, n = 10); (v) Diabetic + Low dose of CoQ10 (100 mg/kg) (DLD, n = 10); (vi) Diabetic + high dose of CoQ10 (600 mg/kg) (DHD, n = 10). Diabetes was induced by a single intraperitoneal injection of 50 mg/kg STZ. CoQ10 was administered intragastrically by gavage once a day for 90 days. After 90 days, Morris water maze (MWM) task was used to evaluate the spatial learning and memory in rats. Diabetic animals showed a slower rate of acquisition with respect to the control animals [F (1, 51) = 92.81, P < 0.0001, two-way ANOVA]. High dose (but no low dose) supplementation with CoQ10 could attenuate deteriorative effect of diabetes on memory acquisition. Diabetic animals which received CoQ10 (600 mg/kg) show a considerable decrease in escape latency and traveled distance compared to diabetic animals (p < 0.05, two-way ANOVA,). The present study has shown that low dose supplementation with CoQ10 in diabetic rats failed to improve deficits in cognitive function but high dose supplementation with CoQ10 reversed diabetes-related declines in spatial learning.


Diabetes mellitus Coenzyme Q10 (CoQ10) Learning and memory Wistar rats 



The authors would like to express their gratitude to the staff of the Neurophysiology Research Center for helping us to carry out this project. This research was supported by a grant (grant number: IR.UMSHA.REC.1394.360) of the Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Compliance with ethical standards

Conflict of interest statement

We confirm that the authors do not have any conflict of interest with this publication.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Neurophysiology Research CenterHamadan University of Medical SciencesHamadanIran
  2. 2.Department of Neuroscience, School of Advanced Technologies in MedicineHamadan University of Medical SciencesHamadanIran
  3. 3.Department of Physiology, School of MedicineHamadan University of Medical SciencesHamadanIran

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