Effect of coenzyme Q10 supplementation on diabetes induced memory deficits in rats
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The main objective of current work was to determine the effects of low and high dose supplementation with coenzyme Q10 (CoQ10) on spatial learning and memory in rats with streptozotocin (STZ)-induced diabetes. Male Wistar rats (weighing 220 ± 10) were randomly divided into six groups: (i) Control (Con, n = 8); (ii) Control+ Low dose of CoQ10 (100 mg/kg) (CLD, n = 10); (iii) Control+ high dose of CoQ10 (600 mg/kg) (CHD, n = 10); (iv) Diabetic (D, n = 10); (v) Diabetic + Low dose of CoQ10 (100 mg/kg) (DLD, n = 10); (vi) Diabetic + high dose of CoQ10 (600 mg/kg) (DHD, n = 10). Diabetes was induced by a single intraperitoneal injection of 50 mg/kg STZ. CoQ10 was administered intragastrically by gavage once a day for 90 days. After 90 days, Morris water maze (MWM) task was used to evaluate the spatial learning and memory in rats. Diabetic animals showed a slower rate of acquisition with respect to the control animals [F (1, 51) = 92.81, P < 0.0001, two-way ANOVA]. High dose (but no low dose) supplementation with CoQ10 could attenuate deteriorative effect of diabetes on memory acquisition. Diabetic animals which received CoQ10 (600 mg/kg) show a considerable decrease in escape latency and traveled distance compared to diabetic animals (p < 0.05, two-way ANOVA,). The present study has shown that low dose supplementation with CoQ10 in diabetic rats failed to improve deficits in cognitive function but high dose supplementation with CoQ10 reversed diabetes-related declines in spatial learning.
KeywordsDiabetes mellitus Coenzyme Q10 (CoQ10) Learning and memory Wistar rats
The authors would like to express their gratitude to the staff of the Neurophysiology Research Center for helping us to carry out this project. This research was supported by a grant (grant number: IR.UMSHA.REC.1394.360) of the Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
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Conflict of interest statement
We confirm that the authors do not have any conflict of interest with this publication.
- Ahmad M, Saleem S, Ahmad AS, Yousuf S, Ansari MA, Khan MB, Ishrat T, Chaturvedi RK, Agrawal AK, Islam F (2005) Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences. J Neurochem 93:94–104CrossRefGoogle Scholar
- Beal MF (2004b) Therapeutic effects of coenzyme Q10 in neurodegenerative diseases. In: Methods in enzymology. Elsevier, pp 473–487Google Scholar
- Care IoLARCo, Animals UoL, Resources NIoHDoR (1985) Guide for the care and use of laboratory animals: National AcademiesGoogle Scholar
- Furman BL (2015) Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharmacol 70:5.47.1–20Google Scholar
- Hajisoltani R, Karimi SA, Rahdar M, Davoudi S, Borjkhani M, Hosseinmardi N, Behzadi G, Janahmadi M (2019) Hyperexcitability of hippocampal CA1 pyramidal neurons in male offspring of a rat model of autism spectrum disorder (ASD) induced by prenatal exposure to valproic acid: a possible involvement of Ih channel current. Brain Res 1708:188–199CrossRefGoogle Scholar
- Lenaz G, Bovina C, Formiggini G, Parenti GC (1999) Mitochondria, oxidative stress, and antioxidant defences. Acta Biochim Pol 46:1–21Google Scholar
- Moradkhani S, Salehi I, Abdolmaleki S, Komaki A (2015) Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and memory in streptozotocin-induced diabetic rats. Anc Sci Life 34:157Google Scholar
- Rauchova H, Drahota Z, Lenaz G (1995) Function of coenzyme Q in the cell: some biochemical and physiological properties. Physiol Res 44:209–209Google Scholar
- Shen Q, Pierce J (2015) Supplementation of coenzyme Q10 among patients with type 2 diabetes mellitus. In: Healthcare: Multidisciplinary Digital Publishing Institute. p 296–309Google Scholar
- Vijayakumar T, Sirisha G, Farzana Begam M, Dhanaraju M (2012) Mechanism linking cognitive impairment and diabetes mellitus. European Journal of Applied Sciences 4:1–5Google Scholar
- Zahedi H, Eghtesadi S, Seifirad S, Rezaee N, Shidfar F, Heydari I, Golestan B, Jazayeri S (2014) Effects of CoQ10 supplementation on lipid profiles and glycemic control in patients with type 2 diabetes: a randomized, double blind, placebo-controlled trial. J Diabetes Metab 13:81Google Scholar