Fucoxanthin prevents lipopolysaccharide-induced depressive-like behavior in mice via AMPK- NF-κB pathway
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Fucoxanthin (FX), a natural carotenoid abundant in edible brown seaweeds, has been shown the great anti-oxidant, anti-inflammatory and anti-diabetic effects in vivo and in vitro. The present study was designed to investigate the effects of FX on lipopolysaccharide (LPS)-induced behavioral defects in mice. In depressive behavior tests, the increased immobility time of forced swimming test and tail suspension test by LPS treatment in mice, which were significantly reversed by FX treatment (200 mg/kg, i.g.). In anxiety behavior tests, LPS injection was neither influence the anxiety-related parameters in marble burying test nor that in elevated plus maze test. Interestingly, anxiolytic effects were observed in single FX treated control and LPS-induced mice groups. FX treatment also reversed LPS-induced body weight loss and food intake decreases. Biochemical analysis indicated that FX inhibited LPS-induced overexpression of pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α), as well as iNOS and COX-2 in the hippocampus, frontal cortex and hypothalamus, via the modulation of AMPK-NF-κB signaling pathway.
KeywordsFucoxanthin Lipopolysaccharide (LPS) Depression Inflammation AMPK NF-κB
Xi Jiang, Guokang Wang and Qizhi Yan contributed equally to this work. This work was funded by scientific research project of Zhejiang Provincial Natural Science Foundation of China (LGF18H090014) for Xuefeng Yu; Science and technology project of Zhejiang medical and health department (2017182371), Natural Science Foundation of Ningbo (2017A610175) for Xi Jiang; Shaoxing health and family planning science and technology project (2017QN005), Shaoxing People’s Hospital scientific research project (2017B13) for Qizhi Yan.
Xi Jiang, Qizhi Yan and Xuefeng Yu designed the research study. Xi Jiang, Qizhi Yan and Guokang Wang conducted the experiments. Xi Jiang and Xuefeng Yu analyzed the data. Zhihua Tang, Guokang Wang, Qian Lin and Xuefeng Yu wrote the manuscript.
Compliance with ethical standards
Conflicts of interest
The authors declare no conflict of interest.
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