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Metabolic Brain Disease

, Volume 33, Issue 6, pp 1985–1994 | Cite as

Antioxidant and antidepressant-like effects of Eugenia catharinensis D. Legrand in an animal model of depression induced by corticosterone

  • Sara Cristiane Barauna
  • Débora Delwing-Dal Magro
  • Maitê Beatriz Brueckheimer
  • Thayná P. Maia
  • Geraldo Antonio Bunick Neto Sala
  • André Wolff Döhler
  • Mateus Campestrini Harger
  • Dayse Fabiane Machado de Melo
  • André Luís de Gasper
  • Michele Debiasi Alberton
  • Diogo Alexandre Siebert
  • Gustavo Amadeu Micke
  • Cláudia Almeida Coelho de Albuquerque
  • Daniela Delwing-De Lima
Original Article
  • 148 Downloads

Abstract

This work investigated the antioxidant and antidepressant-like effects of ethyl acetate extract from Eugenia catharinensis in mice treated with corticosterone (20 mg/Kg). The animals received saline or corticosterone (21 days) and, in the last 7 days, they were treated with the extract (50, 125, 200 or 250 mg/Kg) or vehicle. After 24 h, the mice were submitted to the open field and forced swimming tests, after which the hippocampus and cerebral cortex were removed. Our results showed that the extract decreased the immobility time of mice in the forced swimming test and that the extract was able to reverse the effect caused by corticosterone. Corticosterone pre-treatment generated oxidative stress, altering antioxidant enzymes in the nervous tissue. The extract increased the catalase and superoxide dismutase activities and reversed the effects of corticosterone. In the hippocampus, the extract increased superoxide dismutase activity and reversed the increase in catalase activity elicited by corticosterone. We propose that the effects elicited by the Eugenia catharinensis are dependent on the presence of phenolic compounds (gallic acid, protocatechuic acid, syringic acid, 4-hydroxy methylbenzoic acid, chlorogenic acid, salicylic acid, caffeic acid, vanillic acid, p-coumaric acid, isoquercetin, rutin, ferulic acid, aromadendrin, galangin and apigenin) in this extract, as demonstrated by HPLC-ESI-MS/MS.

Keywords

Myrtaceae Depression Oxidative stress Phenolic compounds 

Notes

Acknowledgements

This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (grant number 431280/2016-9), Fundação de Amparo à Pesquisa do Estado de Santa Catarina (grant number 1066/2016), Universidade da Região de Joinville and Universidade Regional de Blumenau.

Compliance with ethical standards

Conflict of interest

The authors declare no competing financial interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Sara Cristiane Barauna
    • 1
    • 2
  • Débora Delwing-Dal Magro
    • 2
  • Maitê Beatriz Brueckheimer
    • 3
  • Thayná P. Maia
    • 3
  • Geraldo Antonio Bunick Neto Sala
    • 3
  • André Wolff Döhler
    • 2
  • Mateus Campestrini Harger
    • 2
  • Dayse Fabiane Machado de Melo
    • 4
  • André Luís de Gasper
    • 2
  • Michele Debiasi Alberton
    • 4
  • Diogo Alexandre Siebert
    • 5
  • Gustavo Amadeu Micke
    • 5
  • Cláudia Almeida Coelho de Albuquerque
    • 2
  • Daniela Delwing-De Lima
    • 1
    • 3
  1. 1.Programa de Pós-Graduação em Saúde e Meio AmbienteUniversidade da Região de Joinville– UNIVILLEJoinvilleBrazil
  2. 2.Departamento de Ciências Naturais, Centro de Ciências Exatas e NaturaisUniversidade Regional de BlumenauBlumenauBrazil
  3. 3.Departamento de MedicinaUniversidade da Região de Joinville– UNIVILLEJoinvilleBrazil
  4. 4.Departamento de Ciências Farmacêuticas, Centro de Ciências da SaúdeUniversidade Regional de BlumenauBlumenauBrazil
  5. 5.Departamento de Química, Centro de Ciências Físicas e MatemáticasUniversidade Federal de Santa CatarinaFlorianópolisBrazil

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