Metabolic Brain Disease

, Volume 33, Issue 6, pp 1955–1959 | Cite as

Correlation of serum levels and gene expression of tumor necrosis factor-α-induced protein-8 like-2 with Parkinson disease severity

  • Ebrahim Kouchaki
  • Reza Daneshvar Kakhaki
  • Omid Reza Tamtaji
  • Ehsan DadgostarEmail author
  • Mohammad Behnam
  • Alireza Zaribaf
  • Hassan NikoueinejadEmail author
  • Hossein Akbari
  • Zatollah Asemi
Original Article


Different immune-mediated mechanisms involved in the pathogenesis of Parkinson disease (PD) as a neurodegenerative and inflammatory disease. According to our knowledge, there is no report evaluating Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2), a cytokine maintaining immune homeostasis, in PD. We analyzed the correlation of the serum levels and circulatory gene expression of TIPE2 with severity of PD. In this case-control study, 43 patients with PD and 40 healthy subjects were enrolled. The diagnosis of PD was performed byclinical diagnostic criteria of the UK Parkinson’s Disease Society Brain Bank. The severity of PD was evaluated by modified Hoehn and Yahr (H and Y) scale. Serum levels and gene expression of TIPE2 were assessed by Elisa and real time PCR, respectively. The mean serum levels and gene expression of TIPE2 in patients with PD did not have significant difference compared to healthy subjects. Linear multiple regression analysis showed that increased serum levels of TIPE2 are positively related to age and severity of PD (P ≤ 0.0001). In addition, the gene expression of TIPE2 was found to be associated with age (P < 0.0001). Our study showed that the serum levels of TIPE2 and its gene expression might be important prognostic biomarkers of PD.


Parkinson disease TIPE2 TNFAIP8 Gene expression 



This work was supported by grants from the Deputy of Research, Kashan University of Medical Sciences, Kashan, Iran (No. 95124).

Author’s contributions

ED and HN contributed in the conception or design of the work, analysis and drafting of the manuscript. EK, RD-K, O-RT, MB, AZ and HA contributed in conception and manuscript drafting. ZA contributed in revised version. The final version was confirmed by all authors for submission.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyKashan University of Medical SciencesKashanIran
  2. 2.Halal Research Center of IRI, FDATehranIran
  3. 3.Physiology Research CenterKashan University of Medical SciencesKashan, I.R.Iran
  4. 4.Student Research CommitteeKashan University of Medical SciencesKashanIran
  5. 5.Department of ImmunologyBaqiyatallah University of Medical SciencesTehranIran
  6. 6.Nephrology and Urology Research CenterBaqiyatallah University of Medical Sciences, Baqiyatallah HospitalTehran, I.RIran
  7. 7.Department of Biostatistics and Public Health, Faculty of HealthKashan University of Medical SciencesKashanIran
  8. 8.Research Center for Biochemistry and Nutrition in Metabolic DiseasesKashan University of Medical SciencesKashan, I.R.Iran

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