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Metabolic Brain Disease

, Volume 33, Issue 6, pp 1849–1857 | Cite as

Correlation of PICALM polymorphism rs3851179 with Alzheimer’s disease among Caucasian and Chinese populations: a meta-analysis and systematic review

  • Bin Zhu
  • Li-Xia Li
  • Lei Zhang
  • Shu Yang
  • Yue Tian
  • Shan-Shan Guo
  • Wei Zhang
  • Zhi-Gang Zhao
Original Article

Abstract

The rs3851179 which located at upstream of PICALM was reported to be associated with Alzheimer’s disease (AD); however, the relationship is still undefined. To gain a more precise understanding of the association, we conducted a meta-analysis: a comprehensive survey of 16 case-control studies that evaluated the role of rs3851179 gene variants in AD patients. The overall analysis revealed a significant association between the polymorphism and AD in the allelic, homozygote, heterozygote, dominant, and recessive models (p < 0.05). When stratified by ethnicity, a significant association was observed between AD development in Caucasian populations and the five-genetic models; Asian populations, however, featured a significant association in only the allelic, homozygote, and recessive models. We did not observe any influence of APOE ε4 carrier status on the incidence of AD and rs3851179 (p > 0.05). Our meta-analysis thus suggested that the PICALM rs3851179 polymorphism was associated with AD; the APOE ε4 status did not influence the relationship. Nevertheless, considering the limitations of our meta-analysis, further large-scale studies should be conducted to gain a more comprehensive understanding.

Keywords

PICALM Alzheimer’s disease rs3851179 APOE ε4 Polymorphism 

Notes

Acknowledgments

This work was supported by Beijing Municipal Administration of Hospitals’ Youth Programme (grant number: QML20170703), China Postdoctoral Science Foundation (No.2017M620700), Beijing Natural Science Foundation (grant number:7164256), The National Key Research and Development Program of China (grant number: 2016YFC1306300) and The Key Project of Natural Science Foundation of Beijing, China (grant number:4161004).

Author’s contributions

BZ. and ZGZ designed this study and had full access to all of the data in the study; LXL and SYA acquisition of data, LZ, YT and SSG analysis and interpretation of data. WZ Critical revision of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pharmacy, Beijing Tiantan HospitalCapital Medical UniversityBeijingChina
  2. 2.Department of Geriatrics, Beijing Tiantan HospitalCapital Medical UniversityBeijingChina
  3. 3.Department of Pharmacy, Beijing Shijitan HospitalCapital Medical UniversityBeijingChina

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