Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers
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Methamphetamine is a popular psychostimulant worldwide which causes neurotoxicity and neuroinflammation. Although previous studies have characterized potential associations between addictive drugs and fasting blood glucose, the influence of methamphetamine on the blood glucose is still largely unknown. The present study was designed to investigate the change of fasting blood glucose of methamphetamine abusers and to confirm the impairment of liver and kidney. Fasting blood glucose was significantly decreased in methamphetamine abusers and in a high-fat diet mouse model with methamphetamine treatment discontinuation. Serum level of ALT, creatine kinase and creatinine were increased in methamphetamine abusers. Serum level of ALT and AST were increased in a high-fat diet mouse model after methamphetamine injection, but there was no significant difference in the anatomy of the liver and kidney in high-fat diet treated mice with or without methamphetamine. The levels of ALT and creatinine were also increased in the methamphetamine abusers. This study demonstrated that the level of glucose was decreased in methamphetamine abusers and in high-fat diet-fed mice after methamphetamine treatment discontinuation. The effect of methamphetamine on the levels of blood glucose may provide the evidence that methamphetamine abusers should be keep energy balance due to the low blood glucose.
KeywordsMethamphetamine Serum biochemical parameters Liver Kidney
Central nervous system
High fat diet
Low density lipoproteins cholesterol
High density lipoproteins cholesterol
This work was supported by grants from the National Natural Science Foundation of China (No. 81322048 and No. 81473190).
Y.H. planned and designed the research, supervised and wrote the experiments; Y.H.Z carried out the experiments and wrote the manuscript; Y.B. participated in data acquisition and analysis; G.F.S and J.C participated in the design of study, drafted manuscript and coordinated the lab work; and X.F.C provided the comments on the manuscript, edited the writing, and involved in revising it critically for important intellectual content. All authors read and approved the final manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that there are no conflicts of interest.
- Bowyer JF, Tranter KM, Sarkar S, George NI, Hanig JP, Kelly KA, Michalovicz LT, Miller DB, O'Callaghan JP (2017) Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine. J Neurochem 143:198–213. https://doi.org/10.1111/jnc.14143 CrossRefPubMedPubMedCentralGoogle Scholar
- De La Garza R, Shoptaw S, Newton TF (2008) Evaluation of the cardiovascular and subjective effects of rivastigmine in combination with methamphetamine in methamphetamine-dependent human volunteers. Int J Neuropsychopharmacol 11:729–741. https://doi.org/10.1017/S1461145708008456 CrossRefGoogle Scholar
- Herring NR, Schaefer TL, Tang PH, Skelton MR, Lucot JP, Gudelsky GA, Vorhees CV, Williams MT (2008) Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC Neurosci 9:49. https://doi.org/10.1186/1471-2202-9-49 CrossRefPubMedPubMedCentralGoogle Scholar
- Homer BD, Solomon TM, Moeller RW, Mascia A, DeRaleau L, Halkitis PN (2008) Methamphetamine abuse and impairment of social functioning: a review of the underlying neurophysiological causes and behavioral implications. Psychol Bull 134:301–310. https://doi.org/10.1037/0033-2909.134.2.301 CrossRefPubMedGoogle Scholar
- Huang R, Zhang Y, Han B, Bai Y, Zhou R, Gan G, Chao J, Hu G, Yao H (2017) Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. Autophagy 13:1722–1741. https://doi.org/10.1080/15548627.2017.1356975 CrossRefPubMedPubMedCentralGoogle Scholar
- Jumnongprakhon P, Govitrapong P, Tocharus C, Tocharus J (2016) Melatonin promotes blood-brain barrier integrity in methamphetamine-induced inflammation in primary rat brain microvascular endothelial cells. Brain Res 1646:182–192. https://doi.org/10.1016/j.brainres.2016.05.049 CrossRefPubMedGoogle Scholar
- Lala V, Minter DA (2018) Liver Function Tests. In: StatPearls. Treasure Island (FL),Google Scholar
- Langford D, Grigorian A, Hurford R, Adame A, Crews L, Masliah E (2004) The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus tat protein and methamphetamine on calbindin positive-neurons. J Neurovirol 10:327–337. https://doi.org/10.1080/13550280490520961 CrossRefPubMedGoogle Scholar
- Lee N, Pennay A, Hester R, McKetin R, Nielsen S, Ferris J (2013) A pilot randomised controlled trial of modafinil during acute methamphetamine withdrawal: feasibility, tolerability and clinical outcomes. Drug Alcohol Rev 32:88–95. https://doi.org/10.1111/j.1465-3362.2012.00473.x CrossRefPubMedGoogle Scholar
- Pachmerhiwala R, Bhide N, Straiko M, Gudelsky GA (2010) Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain. Eur J Pharmacol 644:67–72. https://doi.org/10.1016/j.ejphar.2010.07.004 CrossRefPubMedPubMedCentralGoogle Scholar
- Parikh NU, Aalinkeel R, Reynolds JL, Nair BB, Sykes DE, Mammen MJ, Schwartz SA, Mahajan SD (2015) Galectin-1 suppresses methamphetamine induced neuroinflammation in human brain microvascular endothelial cells: Neuroprotective role in maintaining blood brain barrier integrity. Brain Res 1624:175–187. https://doi.org/10.1016/j.brainres.2015.07.033 CrossRefPubMedPubMedCentralGoogle Scholar
- Ros S, Zafra D, Valles-Ortega J, García-Rocha M, Forrow S, Domínguez J, Calbó J, Guinovart JJ (2010) Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis. J Biol Chem 285:37170–37177. https://doi.org/10.1074/jbc.M110.157396 CrossRefPubMedPubMedCentralGoogle Scholar
- Ros S, Garcia-Rocha M, Calbo J, Guinovart JJ (2011) Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats. Diabetologia 54:2639–2648. https://doi.org/10.1007/s00125-011-2238-x CrossRefPubMedGoogle Scholar
- Sekine Y, Minabe Y, Ouchi Y, Takei N, Iyo M, Nakamura K, Suzuki K, Tsukada H, Okada H, Yoshikawa E, Futatsubashi M, Mori N (2003) Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms. Am J Psychiatry 160:1699–1701. https://doi.org/10.1176/appi.ajp.160.9.1699 CrossRefPubMedGoogle Scholar
- Shima N, Miyawaki I, Bando K, Horie H, Zaitsu K, Katagi M, Bamba T, Tsuchihashi H, Fukusaki E (2011) Influences of methamphetamine-induced acute intoxication on urinary and plasma metabolic profiles in the rat. Toxicology 287:29–37. https://doi.org/10.1016/j.tox.2011.05.012 CrossRefPubMedGoogle Scholar
- Shin EJ, Tran HQ, Nguyen PT, Jeong JH, Nah SY, Jang CG, Nabeshima T, Kim HC (2017) Role of mitochondria in methamphetamine-induced dopaminergic neurotoxicity: involvement in oxidative stress, Neuroinflammation, and pro-apoptosis-a review. Neurochem Res 43:57–69. https://doi.org/10.1007/s11064-017-2318-5 CrossRefPubMedGoogle Scholar
- Vearrier D, Greenberg MI, Miller SN, Okaneku JT, Haggerty DA (2012) Methamphetamine: history, pathophysiology, adverse health effects, current trends, and hazards associated with the clandestine manufacture of methamphetamine. Dis Mon 58:38–89. https://doi.org/10.1016/j.disamonth.2011.09.004 CrossRefPubMedGoogle Scholar
- Wang Q, Wei LW, Xiao HQ, Xue Y, Du SH, Liu YG, Xie XL (2017) Methamphetamine induces hepatotoxicity via inhibiting cell division, arresting cell cycle and activating apoptosis: in vivo and in vitro studies. Food Chem Toxicol 105:61–72. https://doi.org/10.1016/j.fct.2017.03.030 CrossRefPubMedGoogle Scholar