Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder
- 96 Downloads
Post-traumatic stress disorder (PTSD) is the serious psychiatric disorder. Paeoniflorin (PF) produces the antidepressant-like properties. However, few studies are concerned about its anti-PTSD-like effects and mechanisms. To investigate these, the single prolonged stress (SPS) model was utilized. PTSD-like behavioral deficits in rats after exposure to SPS were improved by PF (10 and 20 mg/kg, i.p.), evidenced by blocking increased freezing time in contextual fear paradigm (CFP) and increased time and entries in open arms in elevated plus maze (EPM) test without affecting the locomotor activity in open field (OF) test. We also found that increased levels of corticosterone (Cort), corticotropin releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) after exposure to SPS were reversed by PF (10 and 20 mg/kg, i.p.) in serum, respectively. Moreover, the decreased levels of serotonin (5-HT) and 5-Hydroxyindoleacetic acid (5-HIAA) in prefrontal cortex and hippocampus were reversed by PF (10 and 20 mg/kg, i.p.), respectively. In summary, the anti-PTSD-like activities of PF were associated with the modulation of HPA axis and 5-HT system activation.
KeywordsHPA axis Monoamines PF PTSD
This study was supported by a grant from Natural Science Foundation of Guangdong Province, China (No. 2017A030313448), National Natural Science Foundation of China (No. 81703731) and Project of Educational Commission of Guangdong Province, China (No. 2016KQNCX086).
Wei Xiao, Qing-Hong Fan, Xiao-Meng Chai and Wei-hai Ye have participated in the revised manuscript and the proof. They had contributed to the revision. Thus, we invited them in the publication.
Compliance with ethical standards
The authors have declared that no competing interests exist.
- Akiki TJ, Averill CL, Wrocklage KM, Schweinsburg B, Scott JC, Martini B et al (2017) The association of PTSD symptom severity with localized hippocampus and amygdala abnormalities. Chron Stress (Thousand Oaks). https://doi.org/10.1177/2470547017724069
- de Kloet CS, Vermetten E, Rademaker AR, Geuze E, Westenberg HG (2012) Neuroendocrine and immune responses to a cognitive stress challenge in veterans with and without PTSD. Eur J Psychotraumatol 3Google Scholar
- George SA, Rodriguez-Santiago M, Riley J, Rodriguez E, Liberzon I (2015) The effect of chronic phenytoin administration on single prolonged stress induced extinction retention deficits and glucocorticoid upregulation in the rat medial prefrontal cortex. Psychopharmacology 232:47–56CrossRefPubMedGoogle Scholar
- Li YF, Huang Y, Amsdell SL, Xiao L, O'Donnell JM, Zhang HT (2009) Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. Neuropsychopharmacology 34:2404–2419CrossRefPubMedPubMedCentralGoogle Scholar
- Miao YL, Guo WZ, Shi WZ, Fang WW, Liu Y, Liu J et al (2014) Midazolam ameliorates the behavior deficits of a rat posttraumatic stress disorder model through dual 18 kDa translocator protein and central benzodiazepine receptor and neurosteroidogenesis. PLoS One 9:e101450CrossRefPubMedPubMedCentralGoogle Scholar
- Oliveira TQ, Sousa CNS, Vasconcelos GS, de Sousa LC, de Oliveira AA, Patrocínio CFV et al (2017) Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone. J Affect Disord 219:49–57CrossRefPubMedGoogle Scholar
- Santos CJ, Ferreira AV, Oliveira AL, Oliveira MC, Gomes JS, Aguiar DC (2016) Carbohydrate-enriched diet predispose to anxiety and depression-like behavior after stress in mice. Nutr Neurosci 29:1–7Google Scholar
- van Rooij SJH, Stevens JS, Ely TD, Hinrichs R, Michopoulos V, Winters SJ, Ogbonmwan YE (2017) The role of the hippocampus in predicting future posttraumatic stress disorder symptoms in recently traumatized civilians. Biol Psychiatry. https://doi.org/10.1016/j.biopsych.2017.09.005