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Metabolic Brain Disease

, Volume 32, Issue 4, pp 1069–1072 | Cite as

Late onset MELAS with m.3243A > G mutation and its association with aneurysm formation

  • Kun Zhu
  • Shuang Li
  • Huan Chen
  • Yao Wang
  • Miao Yu
  • Hongyan Wang
  • Weijie Zhao
  • Yunpeng CaoEmail author
Original Article

Abstract

We reported a 53-year-old with late-onset mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) accompanied by aneurysm and large vessel dilations. Most studies have focused on microangiopathy causing stroke-like episodes. We report a case to describe large vessel involvement in clinical considerations, and possible mechanisms of aneurysm formation. We recommended regular angiographic examination for patients with MELAS.

Keywords

MELAS Aneurysm Nitric oxide synthase Apoptosis 

Abbreviations

MELAS

mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes

NAA

N-acetyl aspartate

NO

nitric oxide

eNOS

endothelial nitric oxide synthase

UIA

unruptured intracranial aneurysm

DSA

digital subtraction angiography

IA

intracranial aneurysm

IL

interleukin

DAMPs

damage associated molecular patterns

COX

cytochrome c oxidase

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Kun Zhu
    • 1
    • 2
  • Shuang Li
    • 1
  • Huan Chen
    • 1
  • Yao Wang
    • 1
  • Miao Yu
    • 1
    • 3
  • Hongyan Wang
    • 4
  • Weijie Zhao
    • 5
  • Yunpeng Cao
    • 1
    Email author
  1. 1.Department of NeurologyFirst Affiliated Hospital of China Medical UniversityShenyangChina
  2. 2.The 96th Class, 7-Year ProgramChina Medical UniversityShenyangChina
  3. 3.The 97th Class, 7-Year ProgramChina Medical UniversityShenyangChina
  4. 4.Department of CadreThe Central Hospital of Jiamusi CityJiamusiChina
  5. 5.Department of NeurologyCapital Medical University Affiliated Beijing Friendship HospitalBeijingChina

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